部分临床药物的拉曼光谱研究.docVIP

PAGE PAGE PAGE 1 PAGE 部分临床药物的拉曼光谱研究 摘要 本文利用拉曼光谱技术对抗生素、抗组织胺、血凝酶和止吐剂等几类常用药物进行了光谱测量，精确确定了其拉曼位移、拉曼峰的强度、包络的线形和谱线线宽等光谱特性，尝试以此为基础建立快速识别检测机制. 研究报告表明:小分子药物的光谱特征很明显，对其进行光谱识别简单易行;大分子都表现出较弱的光谱特征峰, 不仅导致了对其光谱识别的困难,也很难准确确定其位置. 对于不同药物，本文不但提出了用拉曼光谱测量和分析其药物成分的可行性，还通过分析其拉曼光谱的特性，为识别和分析其成分提供了实验证据. 本文不仅为建立药物的拉曼光谱数据库奠定了基础.还使业界看到了快速的识别和检测药物的前景. 关键词：拉曼光谱；抗生素；止吐剂；光谱分析 Study on Raman Spectra of Some clinical medicine Abstract The spectroscopic observations of several kinds of medicine, such as antibiotics, antihistamine, hemocoagulase and antiemetics, are carried out with the technique of Raman spectroscopy. The spectral properties are reflected by Raman shift as well as intensity, lineshape and linewidth of Raman envelope. The results show that drugs with small molecule have apparent spectral characteristics, by which to recognize them is very feasible, while those with large molecule have weak peaks in their spectra, leading to a difficult recognition as well as uncertain peak positions. This work not only proposes to identify chemical ingredients of drugs by observing and analyzing their Raman spectra, but also provides experimental evidences for doing so. The present results lay the foundation for establish the database of Raman spectra for drugs, and point out the prospect for rapid identification and detection of drugs. Key Words: Raman spectroscopy；Antibiotics； Antiemetics；Spectral analysis 目 录 第1章 绪论…………………………………………………………………………3 1.1拉曼光谱介绍 ……………………………………………………………………………3 1.2 拉曼光谱特点………………………………………………………………………………3 1.3选题依据……………………………………………………………………………………3 1.4本论文所做的主要工作……………………………………………………………………4 第2章 实验原理以及装置……………………………………………………5 2.1 实验装置及原理…………………………………………………………………………5 2.2 实验方法…………………………………………………………………………………6 2.3 样品制备…………………………………………………………………………………6 第3章 测量结果分析与讨论……………………………………………………8 3.1 抗生素类药物…………………………………………………………………………8 3.1.1 地西泮介绍及光谱分析…………………………………………………………8 3.1.2 奥硝唑介绍及光谱分析…………………………………………………………9 3.1.3其他药物光谱分析…………………………………………………………