曲唑酮与氟西汀治疗抑郁症对照研究.docxVIP

曲口坐酮与氟西汀治疗抑郁症对照研 究 【摘要】 目的 比较曲哇酮与氟西汀治 疗抑郁症的疗效及安全性。 方法 将65例 抑郁症患者随机分为两组，研究组 33例， 给予曲口坐酮50?200mg? d-1治疗，对照组 32例给予氟西汀20? 40mg? d-1治疗，观察 6w,米用汉密顿抑郁量表、汉密尔顿焦虑量 表、临床总体印象量表、副反应量表评定临 床疗效及不良反应。 结果 治疗6w末，两 组各量表评分均较治疗前有显着改善， 研究 组治疗1w末比对照组改善显着，提示研究 组起效快。研究组显效率为 ％有效率为％ 对照组分别为 唏口 ％两组疗效相当。两组不 良反应均较轻微，无需特殊处理。 结论 曲 口坐酮治疗抑郁症疗效显着，安全性高，依从 性好。 【关键词】 抑郁症；曲哇酮；氟西汀；汉 密尔顿抑郁量表 A controlled study of trazodone vs. fluoxetine in the treatment of depression [Abstract 】 Objective To compare the curative effects and safety of trazodone vs. fluoxetine in the treatment of depression. Methods 65 depressive patients were divided into research group(n=33, took trazodone 50~200mg/d) and control group(n=32,did fluoxetine 20~40mg/d) for 6 weeks. The curative effects and adverse reactions were assessed with the HAMD, HAMA, CGISI and TESSrespectively. Results After 6 week treatment, there were significant improvement in scores of all scales compared with pretreatment(P < );at the end of 1st week improvement was significant in the research group than in the control group(P <), which hinted that the research group took effects faster. Effectual and effective rates of trazodone group were % and % and of fluoxetine group 75%and %, respectively (P >). The curative effects of the 2 groups were equivalence(P >). The adverse reactions of both groups were milder and didn ' t need special handling. Conclusion Tazodone has an marked curative effect, higher safety and better compliance. 【Keywords】Depression; trazodone; fluoxetine; HAMD 曲哇酮:1］作为一种新型抗抑郁剂，可选 择性地抑制5羟色胺(5HT)和去甲肾上腺素 的再摄取作用，并可阻断组胺 H1受体，从 而消除抑郁，改善睡眠。具有抗抑郁、抗焦 虑［2］、镇静催眠多重作用:3］。为探讨曲 哇酮治疗抑郁症的疗效和安全性我们与氟 西汀治疗进行了对比研究，现报告如下。 1资料与方法 对象 选取2003年3月?2005年12月在 我院门诊及住院治疗的 65例抑郁症患者为 研究对象。入组标准：符合〈〈中国精神障碍 分类与诊断标准》第 3版抑郁症诊断标准； 汉密顿抑郁量表17项评分>24分；性别， 年龄，病期不限；排除伴有严重躯体疾病、 脑器质性疾病、酒及药物依赖者，妊娠、哺 乳期妇女等。将入组病例按入院顺序随机分 为两组。研究组33例，男16例，女17例， 年龄土，病程土；对照组 32例，男14例, 女18例，年龄土，病程±。两组间治疗前 HAMD汉密尔顿焦虑量表评分及一般资料经 统计学分析，差异均无显着性。 方法 治疗 研究组口服曲哇酮治疗，起始剂量 为每晚50mg? d-1 ,3d后增加为100mg? d-1 ? Bid ,以后根据病情逐渐增加剂量，范围