运动诱导心脏保护机制研究进展.pptx

运动诱导心脏保护机制研究进展;Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Pharmacology & Therapeutics 2010, 128: 191-227.;Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Pharmacology & Therapeutics 2010,128:191-227.;Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Pharmacology & Therapeutics 2010,128:191-227.;Bostrom P, Mann N, Wu J ……. Rosenzweig A, Spiegelman BM. Cell 2010,143:1072-1083.;Bostrom P, Mann N, Wu J ……. Rosenzweig A, Spiegelman BM. Cell 2010,143:1072-1083.;Ooi JYY, Bernardo BC, McMullen JR. Future Med Chem 2014,6:205-222;Cell metabolism 2015;21:584-595. (影响因子17.303);miR-17-3p increases in exercise-induced cardiac growth;miR-17-3p induces cardiomyocytes hypertrophy and proliferation;miR-17-3p promotes cardiomyocytes survival;TIMP-3 is a target gene responsible for cardiaomyocyte proliferation;miR-17-3p indirectly increases the AKT pathway, contributing to cardiomyocytes hypertrophy. ;miR-17-3p indirectly increases the AKT pathway, contributing to cardiomyocytes hypertrophy. ;miR-17-3p is required for exercise induced cardiac growth in vivo ;miR-17-3p protects against myocardial ischemia-reperfusion injury.;;Bei Y…….Xiao J(通讯) . J Cell Mol Med, 2017, doi: 10.1111/jcmm.13078;Schonrock N, Harvey RP, Mattick JS. Circ Res 2012,111:1349-1362.;总结;;Journal of Cardiovascular Translational Research ;Acknowledgemens;Acknowledgements;Welcome to Shanghai University