小议恶性肿瘤的代谢异常.pptxVIP

爱吃糖的肿瘤- 小谈肿瘤的代谢紊乱;Robert A. Weinberg;CD19 CAR-T Cell Therapy;Carl June, MD Director, Translational Research Program Abramson Family Cancer Research Institute Perelman School of Medicine The University of Pennsylvania;Macroscale Metabolic Imaging;Tumor-associated metabolic disorder;Schematic representation of the differences between oxidative phosphorylation, anaerobic glycolysis, and aerobic glycolysis (Warburg effect).;Dr. Otto Warburg in his laboratory of the Kaiser Wilhelm Institute for Biology in Berlin-Dahlem, 1931.;Grant proposal submitted by Otto Warburg to the Emergency Association of German Science in 1921. The application, which consisted of a single sentence, “I require 10,000 marks”, was funded in full. ;The citric acid (Krebs) cycle.;Variables Affecting Traffic Flow Are Analogous to the Regulation of Metabolic Flux;;Lewis Cantley obtained his Ph.D. at Cornell University in Ithaca, New York. In 1978 Cantley became assistant professor of Biochemistry and Molecular Biology at Harvard, being promoted to associate professor in 1981. In 1985 he became a full professor in physiology at Tufts University School of Medicine. In 1985 Cantley made the seminal discovery of the existence of phosphoinositide-3-kinase (PI3K). In 1992 Cantley moved to Harvard Medical School as a Professor of Cell Biology and the Director of the Division of Signal Transduction at the former Beth Israel Hospital.;1. Songyang, Z., Shoelson, SE, Chadhuri, M., Gish, G., Pawson, T., Haser, WG, King, F., Roberts, T., Ratnofsky, S., Lechleider, RJ, Neel, BG, Birge, RB, Fajardo JE, Chou, MM, Hanafusa, H., Schaffhausen, B. and Cantley, LC (1993) SH2 Domains Recognize Specific Phosphopeptide Sequences. Cell 72, 767-778. (Cell杂志30年最佳30篇文章之一） 2. Songyang, Z., Shoelson, SE, McGlade, Olivier, JP, Pawson, T., Bustelo, XR, Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, RA, and Cantley, LC (1994) Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2