Hypopituitarism 腺垂体功能减退症 大课课件.pptx

Hypopituitarism (腺垂体功能减退症) ;Sella turcica（蝶鞍）;1）Positive feedback;Hypothalamus;Hypopituitarism;Etiology(病因学):;Simmond disease: is one kind of hypopituitarism, which accures only in adult. Sheehan’s syndrome: is one kind of hypopituitarism, in which the decreased productions of the anterior pituitary hormones are due to ischemic postpartum（产后） pituitary necrosis（坏死） or septicemia（败血症） after delivery.;manifestation of primary disease manifestation of hypopituitarism Symptoms and signs are depending on the kind of deficient pituitary hormones the degree of the deficiency the rate of disease progression;The presentation is variable and complex. ;The classic loss sequence of pituitary hormone is in the following in sheehan'syndrome:;1、PRL deficiency: can not lactate (泌乳）after delivery 2、Gonadotropin deficiency Amenorrhoea（闭经）、Infertility（不孕） Regression of secondary sexal characteristics 3、Growth hormone (GH) deficiency In adult it is not obvious. ;Symptoms and signs of hypopituitarism 4、TSH deficiency ;Symptoms and signs hypopituitarism 5、ACTH deficiency;;The Presentation is variable and complex.;Investigation 1、Measurement of hormones 2 、Stimulating test ;; 2 、 Stimulating test： ;1) Assessment of the functions of pituitary GHRH or CRF or LHRH is injecting into human’s body, then measure the level of pituitary hormones and target gland hormones.;Hormone from pituitary gland;3、others Hypoglycemia Hypotension Hyposalemia(低钠血症) Anemia（贫血） 4、Imageological examination（影像学检测） CT or MRI X-ray;Diagnosis 1)history of damage to pituitary gland or hypothalamus 2)symptoms and signs related to hormone deficiency 3) evidency of anterior pituitary hormone deficiency;Treatment Hormone replacement All life replacement;1、Adrenal hormone replacement must be first Hydrocortisone 20mg 8AM 10mg 4PM Cortisone 5mg 8AM 2.5mg 4PM Fludrocortisone may b