芳香族化合物合成的综述.pdfVIP

Huccetogullari et al. Microb Cell Fact Microbial Cell Factories /10.1186/s12934-019-1090-4 REVIEW Open Access Metabolic engineering of microorganisms for production of aromatic compounds 1,2 1,2 1,2,3* Damla Huccetogullari , Zi Wei Luo and Sang Yup Lee Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efcient pro- duction of natural and non-natural compounds from renewable non-food biomass. Even though microbial produc- tion of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efcient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based produc- tion of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including l-phenylalanine, l-tyrosine and l-tryptophan. It is expected that more and more engineered microorganisms capable of efciently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass. Keywords: Aromatic compounds, Metabolic engineering, Synthetic biology, Shikimate pathway, Phenylalanine, Tyrosine, Tryptophan Background process. With