调脂护肝方对高脂饲养所致脂肪肝大鼠生化指标的影响临床医学.doc

调脂护肝方对高脂饲养所致脂肪肝大鼠生化指标的影响临床医学 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1：调脂护肝方对高脂饲养所致脂肪肝大鼠生化指标的影响临床医学 1 1 材料与方法 3 2 结果 5 3 讨论 5 文2：人参果总皂苷对高脂饲养大鼠胰岛素敏感指数的影响 7 1 材料与方法 8 2 结果 10 3 讨论 11 参考文摘引言： 12 原创性声明（模板） 14 文章致谢（模板） 14 正文 调脂护肝方对高脂饲养所致脂肪肝大鼠生化指标的影响临床医学 文1：调脂护肝方对高脂饲养所致脂肪肝大鼠生化指标的影响临床医学 【Abstract】Objective To observe theraputic effect of Tiaozhi Hugan decoction treatment and investigate its pharmcodynamic. Methods 64 SD male rats were fed a normal diet for one week then they were randomly divided into two groups ,one was normal group（which were 12 rats）fed normal diet, the other , which were 52 rats fed high fatty diet for 12 weeks. At the end of 13th week, 2 rats from fed normal diet group and 8 rats from fed high fat diet group were scarified to test fatty liver model .Then 44 rats，which were fed high fatty diet，were randomly divided into 4 groups of 11 each：model control group，DongBao GanTai group ,seaweed decoction group and Tiaozhi Hugan decoction group. They were fed high fatty diet continuously for 8 weeks. At the same time model control group rats were given distilled water 10ml/(kg·d) by gastrolavage ，seaweed decoction group rats were fed seaweed decoction 20g/(kg·d).Dongbao Gantai group rats were fed Dong Bao Gantai，/(kg·d),Tiaozhi Hugan decoction group were fed Tiaozhi Hugan decoction 10ml/(dg·d)（contained seaweed 20g /kg）.At the end of 21th week，all rats were scarified，body weight，liver index（liver／body weight ratio）serum triglyceride （TG ）， total cholesterol （ TC ），high deity lipoprotein-cholesterol, （HLD-C ），alanine aminotraferase （ALT）， aspartate aminotraferase,（AST ），superoxide dismutase（SOD） malonyl-dialdehyde （MDA） were assayed . Results Compared with model control group，DongBao Gantai group， the level of body weight，liver index, TC ,TG, ALT,AST in serum in Tiaozhi Hugan decoction group were lower significantly .The level of HLD-C was higher.,the level of MDA in Tiaozhi Hugan decoction was lower significantly, the level o