肝硬化并发自发性腹膜炎患者血浆和腹水中降钙素原变化及其意义临床医学.doc

肝硬化并发自发性腹膜炎患者血浆和腹水中降钙素原变化及其意义临床医学 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1：肝硬化并发自发性腹膜炎患者血浆和腹水中降钙素原变化及其意义临床医学 1 1 资料和方法 3 2 结果 4 3 讨论 4 文2：肝硬化并发自发性腹膜炎临床特点分析 6 1 资料与方法 6 2 结果 8 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 11 正文 肝硬化并发自发性腹膜炎患者血浆和腹水中降钙素原变化及其意义临床医学 文1：肝硬化并发自发性腹膜炎患者血浆和腹水中降钙素原变化及其意义临床医学 【Abstract】Objective To analyse the clinical value of Procalcitonin (PCT) change in plasma and ascitic fluid and its significance in liver cirrhosis patients complicated with spontaneous bacterial peritonitis(SBP) ，combined with the results of cell culture and clinical prognosis. Methods 48 liver cirrhosis patients with ascite(with SBP 20 and without 28) were enrolled in this prospective study, plasma and ascitic levels of PCT were measured by a gold immunochromatographic assay and rapid semiquantitative PCT-Q test. Blood and ascite sample were collected at admission to the hospital (T0) ,and at 24h (T24),and 48h (T48) after admission,and before discharge(T discharge). Ascitic fluid was inoculated in the blood culture bottle bedside. Results The positive rate of plasma and ascitic PCT (> ng/ml) were significantly higher in SBP group than those in without SBP group (P<);There was no significant difference on the positive rate of plasma PCT and ascitic fluid PCT in SBP group （T0、T24、T48）(Ｐ<). The seitivity and specificity of plasma PCT in SBP group with SI was all 100%. The seitivity and specificity of ascitic PCT was % and 100% positive rate of plasma and ascitic PCT was correlate with SI,but not correlated with bacterial culture results. PCT level was reduced rapidly as the disease was recovering,and it was positive woe and maintained high level in two dead cases. Conclusion The detection of plasma and ascitic fluid PCT has an important value in early diagnosis and judgement of prognosis of SBP in liver cirrhosis. 【Key words】 Procalcitonin Spontaneous bacterial peritonitis Liver cirrhosis,Acute phase protein 在肝硬化患者中，自发性腹膜炎（spontaneous bacterial