布托啡诺鼻喷剂在妇科腹腔镜术后镇痛中的应用.docVIP

布托啡诺鼻喷剂在妇科腹腔镜术后镇痛中的应用 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：布托啡诺鼻喷剂在妇科腹腔镜术后镇痛中的应用 1 1 资料与方法 3 2 结果 4 3 讨论 4 文2：氯诺昔康在术后镇痛中的应用 5 1 资料与方法 6 2 结果 7 3 讨论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 布托啡诺鼻喷剂在妇科腹腔镜术后镇痛中的应用 文1：布托啡诺鼻喷剂在妇科腹腔镜术后镇痛中的应用 The Application of Butorphanol Tartrate Nasal Spray for Postoperative Analgesia after Gynaecological Laparoscopic Surgery SHANG Xiongyue,DENG Rong Anesthesia Department,Pukou Hospital of Nanjing,Nanjing,211800,Jiangsu,China 【ABSTRACT】 Objective:To investigate the efficacy and safty of tranasal butorphanol for postoperative analgesia in adult female who suffered gynaecological laparoscopic patients undergoing gynaecological laparoscopic surgery with general anesthesia were enlisted into the test,who were randomly divided into two groups(n=27).Postoperatively,cases in butorphanol group received butorphanol 2mg tranasally,and cases control group received visual analogue scores at 0,15,30,60,180,360min postoperation and coumption of pethidine were changes of mean artery pressure,heart rate,Spo2 and respiratory frequency were incidence of side effects such as vomit,itch and somnolence was compared between two :Tranasal butorphanol produced clear analgesic effect compared with placebo,indicating lower analogue scores at 30,60,180min and demanding less women possessed stable vital sig and side effects were not signifficantly different between two :Tranasal butorphanol could effectively relieve postoperative pain in adult female patients who suffered gynaecological laparoscopic side effects were acceptable. 【KEY WORDS】 Gynecologic Surgical Procedures,Laparoscopy,Analgesia,Butorphanol 布托啡诺（butorphanol）是混合型阿片受体激动剂，主要激动κ受体，对μ受体没有激动作用，对δ受体的活性很低。其镇痛效应强，镇痛时间久，呼吸抑制和药物依赖发生率较低［1］ 。目前，关于布托啡诺的研究多是经椎管内用药镇痛和经静脉镇痛［2］ ，布托啡诺鼻喷剂对术后镇痛的作用很少有 文献 报道。本实验采用随机双盲法观察其用于妇科腹腔镜手术后的镇痛效应及不良反应。 1 资料与方法 一般资料 ～月于我院妇科行腹腔镜手术患者54例，年龄20～45岁，ASAⅠ～Ⅱ级，术前无高血压病史，无肝、肾功能明显异常。 将54例患者随机分为布托啡诺组和对照剂组，每组27例患者。 两组患者的年龄、体重、手术时间均无显著性差异（表1）。表1 两组患者的一般资料