高渗盐对急性氨中毒大鼠脑效应的MR灌注成像.docVIP

高渗盐对急性氨中毒大鼠脑效应的MR灌注成像 文档信息 属性： Doc-0292LW，doc格式，正文9970字。质优实惠，欢迎下载！ 说明： 作为医学资料、临床医学资料的写作参考资料，提供解决怎么写及格式等相关问题。 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 正文 高渗盐对急性氨中毒大鼠脑效应的MR灌注成像 文1：高渗盐对急性氨中毒大鼠脑效应的MR灌注成像 effect of hypertonic saline on rats with acute ammonia intoxication:a study utilizing perfusion-weighted magnetic resonance imaging qin shao-hua， li yuan. department of radiology， huashan hospital， fudan univeity，200000，china [abstract] objective to apply mr perfusion weighted imaging to reflect the changes of the perfusion of rat with acute ammonia poisoning before and after using hypertonic saline. methods 24 male sd rats were randomly divided into four groups:ammonia plus hypertonic saline， ammonia plus saline， saline and hypertonic saline. 12 rats were injected intraperitoneally with ammonium acetate; then 6 rats were injected by femoral vein with hypertonic saline and the other 6 control rats were injected by femoral vein with other groups were only injected by femoral vein with hypertonic saline and saline， after 15min mr perfusion-weighted imaging were performed. nei、msd and mtt topographical maps were achieved by the workstation(，ge). the values of nei、msd and mtt of the right or left seory cortex， caudate-putamen， thalamus， cerebellar hemisphere and the motor cortex were measured. then took mea nei， msd and mtt of two-sides of cerebellar hemisphere rois in each rat，the relative nei， msd and mtt(rnei、rmtt and rmsd) were calculated as ratios to the averged left and right cerebellar the ratios of four groups into statistical analysis. results relative mtt and msd had no remarkable changes in four groups. relative nei(rnei) decreased in group of ammonia plus hypertonic saline in the caudate-putamen rois， which compared with that of ammonia plus saline; had statistical significance(p [key words] cerebral edema; ammonia; perfusion- weighted mr; saline solution; hypertonic 氨中毒学说在急性肝衰竭相关肝性脑病脑水肿的发病机制中居于中心地位。所以弄清楚氨在诱发脑水肿过程中所引起病理生理变化，具有重要意义。研究表明高渗盐溶液明显降低急性肝衰竭病人的脑