MRSA感染的问题和治疗策略演示文稿.pptVIP

稳可信与利奈唑脘在医院内肺炎的治愈率比较 当前28页，共28页，星期日。 * Global map presents data from a number of different surveillance studies Data includes community-associated staphylococci as well as hospital-acquired staphylococci Differences vary from country to country and from region to region, with selective pressures being applied in those areas High resistance in some hospitals has led to a shortage of antimicrobials that combat certain pathogens, eg, vancomycin-resistant enterococci Many hospitals are taking the time to determine if antibiotic therapy is appropriate Results: better diagnosis and reduced antibiotics prescribing MRSA is problematic in all geographic regions Rates much higher than these have also been reported which may be related to whether ICU or non-ICU data is reported Depending on geographic location, ESBLs can vary greatly, although not currently a major issue in US Penicillin resistance to S pneumoniae is also a worldwide problem [Presentation suggestion: Include appropriate data from your institution] * 从26.2％－84％不等。 * * * * Delaying Appropriate Antimicrobial Therapy Results in Greater Mortality Key Point: Two studies showed that delaying appropriate initial antimicrobial therapy resulted in significantly greater mortality Supplemental Information: Lodise et al conducted a retrospective cohort study of patients (n = 167) with bloodstream infection due to S aureus between January 1999 – January 2001 in a Detroit hospital Appropriate early treatment was defined as the use of an agent to which the S aureus isolate was susceptible administered within the defined breakpoint of 44.75 hours after first S aureus-positive blood culture Iregui et al conducted a prospective surveillance and cohort study of patients (n = 107) with ventilator-associated pneumonia at a St Louis teaching hospital Initial delay of appropriate antimicrobial treatment was defined as a lag of ≥ 24 hours before VAP diagnosis and initiation of antimicrobial treatment (at least 1 agent