(3.3)--乙脑的全球负担及疫苗的影响(2000-2015)elife.pdf

(3.3)--乙脑的全球负担及疫苗的影响(2000-2015)elife.pdf

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RESEARCH ARTICLE Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015 1,2 1,3 1 1 Tran Minh Quan , Tran Thi Nhu Thao , Nguyen Manh Duy , Tran Minh Nhat , Hannah Clapham1,4,5†* 1Oxford University Clinical Research Unit, Wellcome Trust Asia Program, Ho Chi Minh City, Viet Nam; 2 Biological Science Department, University of Notre Dame, Notre Dame, United States; 3Virology Department, Institute of Virology and Immunology, University of Bern, Bern, Switzerland; 4Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; 5Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Abstract Japanese encephalitis (JE) is a mosquito-borne disease, known for its high mortality and disability rate among symptomatic cases. Many effective vaccines are available for JE, and the use of a recently developed and inexpensive vaccine, SA 14-14-2, has been increasing over the recent years particularly with Gavi support. Estimates of the local burden and the past impact of

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