CALP1-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE CALP1 Cat. No.: HY-P1077 CAS No.: 145224-99-3 分⼦式: C₄₀H₇₅N₉O₁₀ 分⼦量: 842.08 Sequence: Val-Ala-Ile-Thr-Val-Leu-Val-Lys Sequence Shortening: VAITVLVK 作⽤靶点: Calcium Channel; mGluR; Phosphodiesterase (PDE) 作⽤通路: Membrane Transporter/Ion Channel; Neuronal Signaling; GPCR/G Protein; Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 CALP1 是⼀种钙调蛋⽩ (CaM) 激动剂 (Kd 为 88 µM)，与 CaM EF-hand/Ca2+ 结合位点结合。CALP1 通过抑制 钙通道 (calcium channel) 的开放来阻⽌钙的流⼊和凋亡 (IC50 为 44.78 µM)。CALP1 阻⽌⾕氨酸受体 ( glutamate receptor channels) 通道，并阻⽌存储操作的⾮选择性阳离⼦通道。CALP1 激活 CaM 依赖性磷酸⼆ 酯酶 (phosphodiesterase) 活性。 IC50 & Target Kd: 88 µM (Calmodulin) [4] REFERENCES [1]. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. [2]. R Ten Broeke, et al. Calcium sensors as new therapeuti