HXR9-hydrochloride-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE HXR9 hydrochloride Cat. No.: HY-P3245A 分⼦式: C₁₁₉H₁₉₄ClN₅₃O₂₀S 分⼦量: 2754.67 Sequence Shortening: WYPWMKKHHRRRRRRRRR 作⽤靶点: Apoptosis 作⽤通路: Apoptosis 储存⽅式: Protect from light, stored under nitrogen Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 HXR9 hydrochloride 是⼀种细胞渗透性肽，是 HOX/PBX 相互作⽤ (HOX/PBX interaction) 的竞争性拮抗剂。 HXR9 hydrochloride 拮抗 HOX 与第⼆转录因⼦ (PBX) 之间的相互作⽤，PBX 与旁系同源基因组 1 ⾄ 8 中的 HOX 蛋⽩结合。HXR9 hydrochloride 选择性地减少细胞增殖并促进 HOXA/PBX3 基因⾼⽔平表达的细胞，例 如 MLL 重排的⽩⾎病细胞中的细胞凋亡 (apoptosis) [1] [2] [3]。 体外研究 HXR9 hydrochloride (60μM; 4 hours) blocks the interaction between PBX and HOX [1]. HXR9 hydrochloride (60μM; 2 hours) triggers apoptosis in B16 and primary melanoma cells [1]. HXR9 hydrochloride (60μM; 2 hours) causes specific transcriptional changes [1]. HXR9 hydrochloride (B16 cells) shows antiproliferative activity with an IC50 of 20μM [1]. Western Blot Analysis Cell Line: murine B16melanoma cells Concentration: 60 μM Incubation Time: 4 hours Result: Blo