Ezetimibe-d4-1-SCH-58235-d4-1-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Ezetimibe-d4-1 Cat. No.: HY-17376S1 CAS No.: 1093659-89-2 Synonyms: SCH 58235-d4-1 分⼦式: C₂₄H₁₇D₄F₂NO₃ 分⼦量: 413.45 作⽤靶点: Keap1-Nrf2; Autophagy 作⽤通路: NF-κB; Autophagy 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Ezetimibe-d4 是 Ezetimibe 氘代物。Ezetimibe (SCH 58235) 是有效的胆固醇吸收 (cholesterol-absorption) 抑 制剂。Ezetimibe 是⼀种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂。 体外研究 Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs [1]. REFERENCES [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211- 216. [2]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroe