补肾固筋方法治疗膝骨性关节炎的疗效观察及机制研究的开题报告.docxVIP

补肾固筋方法治疗膝骨性关节炎的疗效观察及机制研究的开题报告 Title: Efficacy and Mechanism of Kidney Tonifying and Tendon Strengthening Methods in the Treatment of Knee Osteoarthritis Introduction: Knee osteoarthritis is a common degenerative disease that mainly affects the elderly population. Currently, the treatment options available for knee osteoarthritis are limited, and there is a need for alternative therapies. Traditional Chinese Medicine (TCM) offers several treatment options for knee osteoarthritis, including the use of kidney tonifying and tendon strengthening methods. However, there is limited scientific evidence on the efficacy and mechanism of these methods. Hence, this study aims to investigate the effectiveness and mechanism of kidney tonifying and tendon strengthening methods in the treatment of knee osteoarthritis. Objectives: 1. To evaluate the clinical efficacy of kidney tonifying and tendon strengthening methods in the management of knee osteoarthritis 2. To explore the potential mechanism of kidney tonifying and tendon strengthening methods in knee osteoarthritis through the analysis of relevant biomarkers 3. To investigate the safety and tolerability of kidney tonifying and tendon strengthening methods in the treatment of knee osteoarthritis Methodology: This study will be a randomized controlled trial that will enroll 100 patients aged 50 years and above with knee osteoarthritis. The patients will be randomly assigned to receive either kidney tonifying and tendon strengthening methods or conventional treatment. The kidney tonifying and tendon strengthening methods will include acupuncture, herbal therapy, and dietary therapy. The conventional treatment will include nonsteroidal anti-inflammatory drugs and physiotherapy. The primary outcome measure will be the improvement in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. The secondary outcome measures will include the serum levels of relevant biomarkers such as transforming growth factor-b