核磁共振代谢组学方法及其在代谢综合症方面的应用研究的中期报告.docxVIP

核磁共振代谢组学方法及其在代谢综合症方面的应用研究的中期报告 （Mid-term Report on the Application of Metabolomics Method Based on Nuclear Magnetic Resonance in Metabolic Syndrome） 摘　要 代谢综合症是一种日益普遍的代谢疾病，其发病机制仍不完全清楚。核磁共振代谢组学技术可以全面地测量生物样品中各种代谢物的含量，同时还可以鉴定代谢物之间的关系，从而揭示代谢通路的变化。本文通过对代谢综合症模型小鼠和正常对照小鼠的血清和尿液样品进行核磁共振代谢组学分析，发现了许多代谢物的明显变化，并结合相关的生物信息学分析，发现了代谢通路的变化和代谢物之间的作用关系。这些发现揭示了代谢综合症发生的复杂机制，为更好地预防和治疗代谢综合症提供了新的思路和方法。 Abstract Metabolic syndrome is an increasingly common metabolic disorder, and its pathogenesis is not fully understood. Nuclear magnetic resonance metabolomics technology can comprehensively measure the content of various metabolites in biological samples, and can also identify the relationships between metabolites, thereby revealing changes in metabolic pathways. In this study, nuclear magnetic resonance metabolomics analysis was performed on serum and urine samples of metabolic syndrome model mice and normal control mice. Many significant changes in metabolites were found, and related bioinformatics analysis was performed to reveal changes in metabolic pathways and the interaction between metabolites. These findings reveal the complex mechanism of metabolic syndrome, and provide new ideas and methods for better prevention and treatment of metabolic syndrome. 关键词： 核磁共振；代谢组学；代谢综合症；生物信息学 Keywords: Nuclear magnetic resonance; metabolomics; metabolic syndrome; bioinformatics