MCE稳定同位素标记物的多领域应用.docx

www.MedChemE

,QKLELWRUV?6FUHHQLQJ/LEUDULHV?3URWHLQV

(PharmaceuticalResearch)

Deutetrabenazine

Tetrabenazine

[3]

4)

5)

1)

2)

3)

6)

PET

[4]

DeuterationinDrugDesign

C

H

C

D

Mayleadto:

PKImprovement

ReductionofToxicity

ReductionofEpimerization

MechanismofAction

denovoDrugDesign

O

ND

HO

O

NH2O

D3CO

F

O

D

NN

EtO

N

D

Tetrabenazine-d6

JNd

Thalidomideanalogue-d

Linoleicacidanalogue-d2

VX-984

1approveddrug

Figure2.Deuterationindrugdesign[4]

(MetabolicResearch)

UPLC/QTOFMS

MS/MS

JixiaYang

13C15N

?6\QXFOHLQ

7

(?6\Q)

[5]

(Proteomics)

(Glycomics)

MichaelJ.Bowman TetraplexStable-IsotopeCodedTag

TetraplexStable-IsotopeCodedTag

[6]

2

MCE

MasterofBioactiveMolecules

(StandardsforEnvironmentalAnalysis)

PCBsPBDEs

ChenchenHuang

GC-qMS

Cl/Br

PCBs/PBDEs

[7]

(ClinicalResearch)

13C

(BiomolecularNMR)

13C

15N

(TraceElementAnalysis)

LinardsKlavins

+

0

-

[8]

38.28

35.51

36.26

33.63

33.81

32.93

30.29

25.65

29.21

29.00

28.09

1.86

0.03

2.56

3.68

1.27

-0.20

-2.17

-6.24

-5.57

-9.89

-12.87

-23.89

-25.31

-25.14

-27.30

-26.98

-27.97

-26.27

-24.05

-24.77

-26.63

-28.60

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3

www.MedChemE

,QKLELWRUV?6FUHHQLQJ/LEUDULHV?3URWHLQV

MCE

6RUDIHQLE Donafenib

6RUDIHQLEG Donafenib(Sorafenibd3) Sorafenib

[9]

6RUDIHQLE 6RUDIHQLEG

Cl

F

FF

H H

O

N

Cl

N

H

F

FF

H H

N

O DD

NDH

MCE

2H13C15N18O

1)

2)

?

3)

?

4)

5)

MCE

2H(D)

2H(D) 1 1 1

2H(D)

HY-B0590S

Tetrabenazine-d6

?DWRP

D

D

D

O

D

O

D

D

CASNo.:1392826-25-3

HY-17357S

Nepafenac-d5

? DWRP D D D

NH2

O

CASNo.:1246814-53-8

HY-10065S1

HY-B0304AS1

Axitinib-d3

N

Dapoxetine-d6hydrochloride

?DWRP

?DWRP

N

DD

6

N

O

H

DN

O

ONH

DDD

DDD

HCl

CASNo.:1126623-89-9

CASNo.:1246814-76-5

HY-16293S

HY-B0801S

Lurbinectedin-d3

O

D

Fexofenadine-d6

?DWRP

HN

N

DD

?DWRP

OH

SO

H

OH

O

N

HH

O

DD

NN

O

D

NH2

H

D

O

HH

HO

DDOOH

CASNo.