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www./ResearchTriangle/Forum/4463/anigenetics.gif
BayesianHierarchicalModelforQTLs
SusanSimmonsUniversityofNorthCarolinaWilmington
Collaborators
Dr.EdwardBoone
Dr.AnnStapleton
Mr.HaikunBao
DNA
Chromosome
Genes
GeneticMap
Chromosome1ofProtozoa
Cryptosporidiumparvum
Chromosome1ofHomosapiens
Alleles
GeneticMapsManymoremapsavailableatKnowinginformationaboutgenesnowallowsustofindassociationsbetweengenesandoutcomes(phenotypes)
SomeexamplesIn1989abreakthroughwasmadeforthediseaseofcysticfibrosis.Location(orlocus)is7q31.2-TheCFTRgeneisfoundinregionq31.2onthelong(q)armofhumanchromosome7(singlegeneresponsibleforthisdisease).Thediseaseariseswhenanindividualhastworecessivecopiesatthislocation.Anindividualwithonedominantandonerecessiveissaidtobeacarrierofthedisease.Geneticscreeningtodeterminedisease.
GreenrevolutionTheGreenRevolutionistheincreaseinfoodproductionstemmingfromtheimprovedstrainsofwheat,rice,maizeandothercerealsinthe1960sdevelopedbyDrNormanBorlauginMexicoandothersunderthesponsorshipoftheRockefellerFoundationCreatednewspeciesofwheatandricethatproducedhigheryield.
QTLBettermedicaltreatmentsandincreasedagricultureareonlytwoexamplesinwhichidentifyingthelocationonthegenomecanhaveanimpact.Identifyingtheregiononthegenome(oronthechromosome)responsibleforaquantitativetrait(asopposedtoqualitativeasdisease)isknownasQuantitativeTraitLocus(QTL).
ExistingsoftwareZhao-BangZeng’sgroupatNCStatehasQTLCartographerKarlBroman(JohnHopkins)hasanRprogramthatperformsanumberofalgorithmsforQTLsTousethesealgorithms(andanumberofotherpublishedalgorithms)onlyoneobservationpergenotypecanbeused
Worldofplants
Whyplants?IncreaseyieldtofeedourincreasingpopulationMakeplantsresistanttoUV-Bexposure
Plants,continuedControlDesignandEnv
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