R547-mesylate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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R547mesylate

Cat.No.:HY-111260

CASNo.:869369-26-6

分⼦式:C₁₉H₂₅F₂N₅O₇S₂

分⼦量:537.56

作⽤靶点:CDK;GSK-3;Apoptosis

作⽤通路:CellCycle/DNADamage;PI3K/Akt/mTOR;StemCell/Wnt;

Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性R547mesylate是⼀种⾼效、选择性的，⼝服有效的ATP竞争性的CDK抑制剂，对CDK1/cyclinB、

CDK2/cyclinE和CDK4/cyclinD1作⽤的Ki值分别为2nM、3nM、1nM[1][2][3][4][5]。

客户使⽤本产品发表的科研⽂献

•Science.2017Dec1;358(6367):eaan4368.

•CellChemBiol.2018Feb15;25(2):135-142.e5.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

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ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R547),apotentandselectivecyclin-dependentkinaseinhibitorwith

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[2].BayésM,RabassedaX,ProusJR.Gatewaystoclinicaltrials.MethodsFindExpClinPharmacol.2007Jul-Aug;29(6):427-37.

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