Cenisertib-benzoate-AS-703569-benzoate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Cenisertibbenzoate

Cat.No.:HY-13072B

CASNo.:1145859-64-8

Synonyms:AS-703569benzoate;R-763benzoate

分⼦式:C₃₁H₃₆FN₇O₃

分⼦量:573.66

作⽤靶点:AuroraKinase;Bcr-Abl;Akt;STAT;FLT3

作⽤通路:CellCycle/DNADamage;Epigenetics;ProteinTyrosine

Kinase/RTK;PI3K/Akt/mTOR;JAK/STATSignaling;Stem

Cell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cenisertib(AS-703569)benzoate是⼀种ATP竞争性的多激酶抑制剂，可抑制Aurora-kinase-

A/B，ABL1，AKT，STAT5,FLT3的活性。Cenisertibbenzoate通过抑制肿瘤肥⼤细胞(MC)中⼏种不同分⼦

靶标的活性抑制其⽣长。Cenisertibbenzoate抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以

及⽩⾎病的肿瘤⽣长。

客户使⽤本产品发表的科研⽂献

•Patent.US20210299273A1.

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REFERENCES

[1].PeterB,etal.Drug-inducedinhibitionofphosphorylationofSTAT5overridesdrugresistanceinneoplasticmastcells.Leukemia.2018

Apr;32(4):1016-1022.

[2].McLaughlinJ,etal.Preclinicalcharacterization