EGFR-IN-127-生命科学试剂-MCE.pdf

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EGFR-IN-127

Cat.No.:HY-168112

分⼦式:C₂₄H₂₄FN₇O₆

分⼦量:525.49

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性EGFR-IN-127是⼀种ATP竞争性EGFR抑制剂，对EGFRdel19和EGFRdel19/T790M/C797S的IC50分别为

136.3nM和161.2nM。EGFR-IN-127具有研究⾮⼩细胞肺癌(NSCLC)的潜⼒。

IC50TargetEGFRex19delEGFR19del/TM/CS

136.3nM(IC50)161.2nM(IC50)

体外研究EGFR-IN-127(compoundb)inhibitsthelungcancercellproliferationofA549,PC-9del19,PC-

9del19/T790M/C797S,andH1975cells,withIC50valuesof0.9464μM,1.1262μM,0.4963μM,and1.4142μ

M,respectively[1].

EGFR-IN-127(100nM-1μM;48h)showsanoticeableinhibitionofcellmigration[1].

CellMigrationAssay[1]

CellLine:PC-9del19/T790M/C797Scells.

Concentration:100nMand1μM

IncubationTime:48h

Result:Revealedanoticeableinhibitionofcellmigration.

REFERENCES

[1].Liang-LiangGuo,etal.Design