Salbutamol-adipate-Albuterol-adipate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Salbutamoladipate

Cat.No.:HY-B1037B

CASNo.:149234-08-2

Synonyms:Albuteroladipate;AH-3365adipate

分⼦式:C₁₃H₂₁NO₃.₁/₂C₆H₁₀O₄

分⼦量:312.38

作⽤靶点:AdrenergicReceptor;ERK

作⽤通路:GPCR/GProtein;NeuronalSignaling;MAPK/ERKPathway;

StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Salbutamol(Albuterol)adipate是⼀种具有⼝服活性的短效的β2肾上腺素受体激动剂。Salbutamoladipate

通过β2-AR/ERK/EMT通路促进胃癌细胞的肿瘤发⽣。Salbutamoladipate⽤于研究哮喘和慢性阻塞性肺疾病

(COPD)引发的⽀⽓管痉挛。

IC50Targetβadrenergicreceptor

体外研究Salbutamol(16μM,24h)adipatesignificantlyinducesEMT,migrationandinvasionbyERK(extracellular

signal-regulatedkinase)phosphorylationingastriccancercells[1].

体内研究Salbutamol(5mg/kg/day,orally,for2consecutiveweeks)adipatecanincreasetumorgrowthinnudemice

withgastriccance[1].

Salbutamol(6mg/kgorallyfor4weeks)adipatehasasignificantprotectiveeffectagainstSTZ(HY-13753)-

inducedskeletalmuscleatrophyindiabeticrats[2].

客户使⽤本产品发表的科研⽂献

•AdvSci(Weinh).2024Sep4:e2402393.

•RespirRes.2022D