Opaganib-hydrochloride-ABC294640-hydrochloride-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Opaganibhydrochloride

Cat.No.:HY-16015A

CASNo.:1185157-59-8

Synonyms:ABC294640hydrochloride

分⼦式:C₂₃H₂₆Cl₂N₂O

分⼦量:417.37

作⽤靶点:SphK

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Opaganib(ABC294640)hydrochloride是⼀种选择性的竞争性的鞘氨醇激酶2(SK2)抑制剂，Ki为9.8μM。

客户使⽤本产品发表的科研⽂献

•ArchMedRes.2018Jul;49(5):335-341.

•BiochimBiophysActaMolBasisDis.2018Nov;1864(11):3824-3836.

•FASEBJ.2019Mar;33(3):3636-3646.

•NeurocritCare.2021Sep10.

•Channels.2020Dec;14(1):216-230.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].FrenchKJ,etal.PharmacologyandantitumoractivityofABC294640,aselectiveinhibitorofsphingosinekinase-2.JPharmacolExp

Ther.2010Apr;333(1):129-39.

[2].BeljanskiV,etal.Combinedanticancereffectsofsphingosinekinaseinhibitorsandsorafenib.InvestNewDrugs.2011Dec;29(6):1132-

42.

[3].ShiY,etal.Sphingosinekinase-2inhibitionimprovesmitochondrialfunctionandsurvivalafterhepaticischemia-reperfusion.JHepatol.

2012Jan;56(1):137-45.

[4].LiuQ,etal.Inhibitionofsphingosinekinase-2suppressesinflammationandattenuatesgraftinjuryafterlivertransplantationinrats.

1/2