影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后因素分析.pdf

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主鬯星里塞堕旦箜鲞第6期ChinJRehabilTh∞rYPractice，Jun．2006，VoI．12，No．6

·临床研究·

影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后因素分析

齐高强，王迎选，崔书祥，戴相昆

[摘要]目的探讨影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后的因素。方法95例鼻腔副鼻窦恶性肿瘤患者术后接受放

疗，生存率计算采用Kaplan—Meier法，生存率差异检验采用I．ogrank法，多因素分析采用Cox模型。结果本组患者1、3、5、10年总

生存率分别为84．2、50．5、44．2和2O。单因素分析显示，性别、年龄、手术方法和肿瘤剂量与生存率无相关性，而临床分

期、病理类型与生存率相关。多因素分析显示，I临床分期、病理类型是影响预后的独立因素。视力障碍、听力障碍、口干是治疗的主

要毒副作用。结论术后放疗能提高鼻腔副鼻窦恶性肿瘤的疗效；I临床分期、病理类型是影响放疗预后的重要因素。

[关键词]鼻腔副鼻寞恶性肿瘤；术后放射治疗；副作用

FactorsRelatedwithTherapeuticEffectandPrognosisofPostoperativeRadiotherapyforNasalandParanasalSinusesCarcinomaQI

Gao—qiang，WANGYing—xuan，CUIShu—xiang，eta1．TheDepartmentofRadiationOncology，theGeneralHospitalofPLA，

Beijing100853，China

Abstract：ObjectiveToinvestigatethefactorsrelatedwithcurativeeffectandprognosisofpostoperativeradiotherapyfornasal

andparanasalsinusescarcinoma．MethodsThedataof95patientswithnasalandparanasalsinusescarcinomaandreceivedpostopera—

tiveradiotherapywerereviewedretrospectively．Kaplan—MeiermethodwasusedtOanalyzethesurvival，LogranktestusedtOcom—

parethedifferencesbetweendifferentgroups．MultivariateanalysiswasperformedbyCoxproportionalhazardmode1．ResultsThe0一

verall1，3，5，10一yearsurvivalratesof95patientswere84．2，50．5，44．2and20respectively．Univariateanalysisshowed

thatsex，age，operativemodalityandtumordosewerenotrelatedwithsurviva1．Histologicalandclinicalstageswererelatedwith

surviva1．Multivariateanalysisindicatedthathistologicalandclinicalstageswereindependentprognosticfactors．Thefollow-upre—

suhsshowedthatvisualdisturbance，xerostomia，dysaudiawerethemajorsideeffects．ConclusionPostoperativeradiotherapycan

improvetherapeuticeffectinthetreatmentofnasalandparanasalsinusescarcinoma，andhistologicalandclinic