PROTAC-BRD4-Degrader-30-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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PROTACBRD4Degrader-30

Cat.No.:HY-172827

分⼦式:C₄₈H₅₇N₉O₈

分⼦量:888.02

作⽤靶点:PROTACs;EpigeneticReaderDomain

作⽤通路:PROTAC;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PROTACBRD4degrader-30是⼀种基于ISOX-DUAL的PROTAC降解剂，靶向BRD4(IC50=65nM)。

PROTACBRD4degrader-30可⽤于c-Myc癌蛋⽩和癌细胞病理⽣理学的研究。(粉⾊：BRD4配体(HY-

172828)；蓝⾊：CRBN配体(HY-103596)；⿊⾊：连接⼦(HY-Y0139)；CRBN-配体+连接⼦：HY-138847)

[1]。

IC50TargetBRD4

65nM(IC50)

体外研究PROTACBRD4degrader-30(40nM-40μM,15min)showsnoobservableubiquitinationforthedegraders

withshorterlinkers[1].

REFERENCES

[1].EdmondsAK,etal.,Structure-GuidedDesignofISOX-DUAL-BasedDegradersTargetingBRD4andCBP/EP300:ACaseofDegrader

Collapse.JMedChem.2025Apr17.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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