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Tubulin-IN-55

Cat.No.:HY-175874

CASNo.:353258-94-3

分⼦式:C₂₁H₂₆N₄O

分⼦量:350.46

作⽤靶点:Microtubule/Tubulin;PI3K;Akt;Apoptosis

作⽤通路:CellCycle/DNADamage;Cytoskeleton;PI3K/Akt/mTOR;

Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Tubulin-IN-55是⼀种tubulin抑制剂。Tubulin-IN-55可破坏癌细胞中的PI3K/Akt信号通路。Tubulin-IN-55

对多种肿瘤细胞(HeLa、HCT116、4T1、A549、H1299、MDA-MB231)表现出⼴谱的抗增殖活性。Tubulin-

IN-55可诱导G2/M期阻滞和凋亡(apoptosis)，并抑制癌细胞的迁移/侵袭。Tubulin-IN-55在原位⾃体移植⼩

⿏模型中展现出显著的抗肿瘤功效。Tubulin-IN-55可⽤于癌症研究[1]。

体外研究Tubulin-IN-55(Compound89)(0.1-10μM,24h)showspotentantiproliferativeactivityagainstHeLa,

HCT116,and4T1cells,withIC50valuesof1.20μM,4.91μM,1.13μM,and0.65μM,respectively[1].

Tubulin-IN-55(0.3-0.9μM,12-24h)exhibitsanti-migratoryandanti-invasiveeffectsonHeLa,HCT116,and

4T1cells[1].

Tubulin-IN-55(0.3-1.2μM,24h)inducesapoptosisandG2/MphasearrestinHeLa,HCT116,and4T1cells

[1].

Tubulin-IN-55(6.25-100μM,60min)inhibitstubulinpolymerizationinvitroin