《口腔生物学》Microbial Interaction with the Host in Pericodontal Diseases.ppt

Li Deyi Main Points: The virulence factors of periodontal pathogens The interaction of pathogens with the host in periodontal diseases Contents of this lesson: Text book: P27-32 P150-152 Supplementary reading material 一. Preface Bacteria 二. Microbiologic Aspects of the Microbe - Host Interaction 1. Colonization and Survival in the Periodontal Regionattachment(附着) or adhesion, multiplication(繁殖) and growth 2. Bacterial Invasion(入侵) of Host Tissue 3. Bacterial Evasion (逃避) of Host Defense Degradation of specific antibody Pg (IgA, IgG) Inhibition of IL-8 (production by EC) Pg Kill Leukocytes (produce leukotoxin) Aa (neutrophils, monocytes, lymphocytes) 4. Microbial Mechanisms of Host Tissue Damage Metabolic Products Ammonia Volatile sulfur compounds Fatty acids Peptides Indole 5. Calculus – Calcified Dental Plaque 三. Immunologic Aspects of the Microbe-Host Interaction 1. Neutrophils (嗜中性白细胞) Transendothelial migration (迁移) Chemotaxis (趋化) Opsonization (调理素) Phagocytosis (吞噬) Intraphagolysosomal (吞噬溶酶体) killing 2. Proteinases Matrix metalloproteinases, MMPs (基质金属蛋白酶) Degrade extracellular matrix molecules Collagen Gelatin Elastin 3. Cytokines (细胞因子) Interleukin-1 (IL-1) IL-1α IL-1β Osteoclast activating factor Tumor necrosis factor (TNF) TNFα TNFβ TNFγ Stimulation of bone resorption 4. Prostaglandins (前列腺素) Arachidonic acid(花生四烯酸) metabolities generated by cyclooxygenases(环氧化酶) 20-carbon polyunsaturated fatty acid associated with inflammation and bone loss produced by macrophagesand fibroblasts Summary Periodontal diseases are initiated by bacteria The bacteria can exert direct effects on the periodontal tissues by production of enzymes and cytotoxic agents Agents from dental plaque biofilm are also capable of stimulating host-mediated responses that can lead to destruction of the periodontal tissues Refer