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(重点参考)TAM在肿瘤侵袭和转移中的作用.pdf
Review Article
Tumor-Associated Macrophage: Its Role in Cancer
Invasion and Metastasis
1 1
Jin-Yuan Shih, Ang Yuan , Jeremy J.-W. Chen, and Pan-Chyr Yang
Department of Internal Medicine [J.-Y. Shih, P.-C. Yang] and Department of Emergency Medicine [A. Yuan], National
Taiwan University Hospital, Taipei, Taiwan; Center for Genomic Medicine, National Taiwan University College of
Medicine, Taipei, Taiwan [J. J.-W. Chen, P.-C. Yang]; Institutes of Biomedical Sciences and Molecular Biology,
National Chung-Hsing University, Taichung, Taiwan [J. J.-W. Chen]
Cancer metastasis is not exclusively regulated by the deregulation of metastasis-
promoting or suppressing genes in cancer cells. The interaction between cancer cells
and the stromal cells has been shown recently to promote cancer metastasis. The
macrophages within the tumor, referring to as tumour-associated macrophages
(TAMs), are the pivotal member of stromal cells. TAMs are derived from peripheral
blood monocytes recruited into the tumor. Upon activated by cancer cells, the TAMs
can release a vast diversity of growth factors, proteolytic enzymes, cytokines, and in-
flammatory mediators. Many of these factors are key agents in cancer metastasis.
The presence of extensive TAM infiltration has been shown to correlate with cancer
metastasis and poor prognosis in a variety of human carcinomas. TAMs promote can-
Keywords :
cer metastasis
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