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Lactobacillus rhamnosus CCFM 1107 treatment ameliorates
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alcohol-induced liver injury in a mouse model of chronic
alcohol feeding#
CHI Feifei1, TIAN Fengwei1, WANG Gang1, LIU Xiaoming1, ZHANG Qiuxiang1,
ZHANG Hao1, CHEN Wei1,2**
(1. School of Food Science and Technology, Jiangnan University, JiangSu WuXi 214122;
2. State Key Laboratory of Food Science and Technology, Jiangnan University,
JiangSu WuXi 214122)
Abstract: Lactobacillus rhamnosus CCFM 1107 was screened for high antioxidative activity from over
50 lactobacilli. The present study attempted to explore the in vivo protective properties of Lactobacillus
rhamnosus CCFM1107 in alcoholic liver injury. A mouse model was induced by orally feeding alcohol
by gavage when simultaneously treated with Lactobacillus rhamnosus CCFM 1107, the drug
Hu-Gan-Pian, Lactobacillus rhamnosus GG, and Lactobacillus plantarum CCFM 1112 for 3 months.
Biochemical analysis was performed for both serum and liver homogenate. Detailed intestinal flora and
histological analyses were also carried out. Our results indicated that the administration of
Lactobacillus rhamnosus CCFM 1107 signi?cantly inhibited the increase in the levels of serum
aminotransferase and endotoxin, as well as the content of triglycercide and cholesterol in the serum and
in the liver. Glutathione, glutathione peroxidase and superoxide dismutase were elevated while the
levels of malondialdehyde were decreased. The enteric dysbiosis caused by alcohol was restored by
increasing the numbers of both lactobacilli and bifidobacteria and decreasing the numbers of both
enterococci and enterobacter. Histological analysis confirmed the protective effect of Lactobacillus
rhamnosus CCFM 1107. In contrast to the other lactobacilli and to the drug administered in the study,
we conclude that Lactobacillus rhamnosus CCFM 1107 provides a protective effect on alcoholic liver
injury by reducing oxidative stress and restoring the intestinal flora.
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