糖类抗原153、癌胚抗原、环氧合酶2联合检测在乳腺癌诊断中的应用.pdfVIP

·论著· 糖类抗原15—3、癌胚抗原、环氧合酶一2联合 检测在乳腺癌诊断中的应用 李本传高美华 【摘要】 目的探讨糖类抗原15—3(CAl5．3)、癌胚抗原(CEA)、环氧合酶．2(COX．2)联合检测 对乳腺癌早期诊断的应用价值。方法选择经影像学和病理学诊断为乳腺癌患者53例，同时选择同期 良性乳腺病患者61例及同期健康体检者68名，采用电化学发光技术与酶联免疫吸附法(ELISA)分别 4- 检测血清CAl5—3、CEA、COX．2水平。结果乳腺癌组CAl5—3、CEA、COX．2血清水平分别为(34．67 13．20)u／ml、(7．38±3．87)ng／ml、(43．25 4-10．87)ng／ml，与良性乳腺病组和健康对照组血清含量比 较差异具有统计学意义(均P0．01)；CAl5—3、CEA、COX．2联合检测将各项指标单独检测的阳性检出 率提高至84．9％(45／53)，其敏感度提高至84．9％，准确度提高至91．2％。结论三项肿瘤标志物联合 应用能弥补单项肿瘤标志物临床应用的不足，对提高乳腺癌阳性检出率具有一定意义。 【关键词】乳腺肿瘤；肿瘤标志物；联合检测 of of combinationdetection on ofbreastcarcinoma Application CAl5·3，CEA，COX-2diagnosis LI 0Mei··hucL Ben·-chuan,GA ofImmunology,MedicalCollegeof Department QingdaoUnenity,Qingdao 510632，China author：GA0 CorrespondingMei—hua,Email：meihuagao@yahoo．com．ca To thevalueofcombinationdetectionof on 【Abstract】Objectiveinvestigate CAl5—3，CEA，COX一2 of breastcarcinoma．Methods68breastcancer breastdisease eadydiagnosis patients，61benign patients 68heahhieswere of and selected．SerumlevelsCOX一2weredetectedELISA andCEA by technique，CAl5—3 levelsweredetected electroche．miluminescenceR船ultsSerumlevelsofCAl5—3．CEA． by technique． COX一2inbreastcarcinoma group levelswere thanthosein breastdisease and differenceswere higher benign group healthygroup，the combination was was detection，the 84．9％，and 91．2％，which significant(P0．01)．In sensitivity accuracy were than tumormarkerusedinbreastcancer Th