顶空气相色谱法测定萜类物质（Y211）中的甲醇和石油醚.pdfVIP

《现代仪器与医疗》 2013 年 第 19 卷 第 1 期 检验检测 顶空气相色谱法测定萜类物质（Y211）中的 甲醇和石油醚 Determination of macro-porous resin residua in Y211 by headspace gas chromatography 摘  要  目的建立萜类物质（Y211 ）中残留溶剂甲醇和石油醚的顶空气相色谱测定 方法。方法 采用DB-624 毛细管色谱柱，程序升温，氢火焰离子化检测器，顶空温 度 100℃。选用DMF 为溶剂。结果 各待测组分完全分离，线性关系良好，精密度 段 续1 2 *  蔡振华   1 2 RSD% 0.79%~1.29% ，检测限0.060~0.12 μg/mL ，回收率均大于85%。结论此法操 杨婷婷   蒋庆峰 ** Duan Xu1 Cai Zhenhua2 作简单灵敏，结果准确可靠，可用于Y211 中残留溶剂检测。 Yang Tingting1 Jiang Qingfeng2 关键词  顶空气相色谱法 Y211 残留溶剂 甲醇 石油醚 （1. 天津中医药大学  天津  Abstract Objective To establish a method for detecting the residual methanol and petro- 300193；2. 天津药物研究院 药 leumether in Y211 by headspace capillary gas chromatography. Methods The determination 物分析测试中心  天津  was carried out on a DB-624 capillary column with sequential increase of temperature 300193) programming and FID detector. The headspace temperature was set at 100 and the sol- ℃ (1.Tianjin University of Traditional vent was DMF. Results The organic residuals were completely separated. There was good Chinese Medicine, Tianjin 300193; linearity in the experimental concentration. The RSD of precision were 0.79%~1.29%, and 2. Center for Testing and Analysis, the detection limits were in the range of 0.21~1.23μg/mL. The recoveries were above 85%. Tianjin Institute of Pharmaceutical Conclusion The method is simple, sensitive and accurate. It could be used for detection of Research, Tianjin 300193) the residual solvents of