血清降钙素原对中枢神经系统感染性疾病的诊断价值.pdfVIP

·22 · 中国医师进修杂志 2006年 7 月第 29 卷第 7期内科版 　Ch in J Po stgrad M ed, Ju ly 2006 , Vol. 29 ,No. 7A ·临床论著 · 血清降钙素原对中枢神经系统感染性 疾病的诊断价值 王镇山　刘景春 　薛欣 　顾俊明 ( ) ( ) 　　【摘要 】　目的　探讨血清降钙素原 PCT 、C - 反应蛋白 CRP 、外周血白细胞计数对中枢神 经系统感染性疾病的诊断价值 。方法 　采用半定量固相免疫测定法测定 3 1例中枢神经系统感染 ( ) 性疾病患者 细菌性感染组 18例 ,非细菌性感染组 13例 血清 PCT浓度 ,免疫散射速率比浊法测 定 CRP,常规方法检测外周血白细胞 。结果 　血清 PCT对中枢神经系统细菌感染诊断的敏感度为 100. 0% ,特异度为 76. 9% ,优于 CRP ( P = 0. 00 1) ,与白细胞计数阳性率比较 ,差异无统计学意义 ( P 0. 05) 。结论 　血清 PCT测定是中枢神经系统细菌感染的有效指标 。 　　【关键词 】　降钙素原 ; 　C - 反应蛋白; 　中枢神经系统感染 ; 　细菌感染 D iagno sis va lue of serum proca lc iton in in cen tra l nervou s sy stem infection　　WAN G Z hen - shan, L IU J ing - chun, X UE X in, GU J un - m ing. D ep a rtm en t of R esp ira tory D isease, the S econd Aff ilia ted H os p ita l of D a lian M ed ica l Un ivers ity, D a lian 116023, Ch ina 　　【A b stract】　O bjective　To evaluate the diagno sis value of serum p rocalciton in ( PCT) , C - reac tive p rotein ( CRP) and wh ite b lood cell (WBC ) in p atien ts w ith central nervou s system infection. 　 M ethods　Serum PCT was determ ined by sem i - quantitative so lid - p ha se immunoa ssay from 3 1p atien ts ( ) w ith cen tral nervou s system infection 18 w ith bacterial and 13 w ith non - bacterial . CRP wa s m ea sured by u sing imm un ity - tu rb idity m ethod and WBC was counted by rou tine m ethod. 　Results　The sen sitiv ity of PCT was 100. 0% and the sp ecificity was 76. 9% for the diagno sis of p atients w ith bacterial central nervou s system infection . There was no sign ifican t difference between PCT and WBC ( P = 0. 673 ) , PCT