复方丹参滴丸抗高原缺氧作用的研究进展.pdfVIP

复方丹参滴丸抗高原缺氧作用的研究进展 张雪峰1 (青海省格尔木市人民医院 高原病研究中心,格尔木 816000) 摘要 复方丹参滴丸抗缺氧作用的中医药学、生化药理学、分子药理学、临床药理学机制逐渐被 研究,其抗缺氧、抗衰老、抗氧化、抗疲劳、抗辐射、免疫调节等“适应原”样药物作用日益被揭示。 目前已证实复方丹参滴丸具有抗大鼠高原低氧组织病理损害、调节高原人血清生物化学物质代谢、 改善高原习服期基础生理指标与心血管的效应、改善高原血液流变学特征等作用,可用于高原反应、 高原脑水肿、慢性高原病、高原心肌缺血、高原高黏滞血症等急慢性高原病及高原习服、保健、预 防、康复及治疗中,但尚需加强循证医学研究。 关键词 复方丹参滴丸; 高海拔; 缺氧; 适应原 Progress in researches for compound Danshen Dropping Pill in treating altitude hypoxia ZHANG Xue-feng (High Altitude Disease Research Center of People’s Hospital, Germud 816000, China) Abstract The anti-oxidative effects of compound Danshen Dropping Pill (CDDP) have been widely studied in the aspects of traditional Chinese medicine, biochemical pharmacology, molecular pharmacology and clinical pharmacology. The adaptor-like effects of CDDP have been gradually revealed, including its anti-hypoxia, anti-aging, anti-oxidative, anti-fatigue, anti-radiation and immunoregulation effects. Up-to-date it has been found that DSP attenuated histopathological damage in rats, regulated biochemical materials in blood, and improved cardiovascular responses, basic physiological indicators and hemorrheology in the high altitude acclimatization. CDDP is applied in the treatments of plateau response, high altitude cerebral edema, chronic high altitude disease, plateau myocardial ischemia, plateau hyperviscosity syndrome and plateau acclimatization, as well as in health care, prevention, and rehabilitation. These effects of CDDP need to be further verified by introducing evidence-based medicine. Key words compound Danshen dripping pill; high aititude; hypoxia; adaptor-like 复方丹参滴丸(compound Danshen dripping pill,CDDP)是我国心血管领域应用广 [1] 泛的一线现代中药。随着其作用机制研究的不断深入和