多发性骨髓瘤干细胞 表面标记和信号传导通路的作用与意义.pdfVIP

JournalofClinicalRehabilitative丌ssueResearch 7，2010V01．14，No．7 EngmeenngJanuary 多发性骨髓瘤干细胞木★ 表面标记和信号传导通路的作用与意义 鄢艳红，李惠民 ≈№∞#％∞∞自∞Ⅻ㈣∞∞∞∞镕*≈B∞目∞Ⅻ艚女黼女≈镕}瓣，自自黼∞m∞#*自#删w《％m＆S∞％#碱№＆∞％目女％∞目甜≈础十端pⅥ∞々铆^铽m☆*·、舯懈，*一坼1}’，一嘶∞《mm* stemcells：Effectand ofsurfacemarkersand Multiple significance signal myeloma pathways Yan Hui—min Yan-hong，Li Abstract of Department BACKGROUND：Cancerstemcel|isa ofcancercellsin the ofstem Hematology．First minoritypopulation multiplemyelomapossessingproperties Affiliated Hospital differentiationand disease cells：self-renewal，multi-directionallong—termproliferation，whichmediatinginitiation，relapse． Medical Kunming and resistance． progressiondrug College，Kunming OBJECTIVE：Toreviewcharacteristicsof andidentificationin biology，phenotypicanalyses，sorting clonogenicmyelomacells，the 650032，Yunnan Province．China withIn stemcellsandthe related． signalingpathwaysmyeloma targettherapy of searchMedline stem database(1 cells． METHODS：Applicationcomputer 999-01／2009—04)，using“multiplemyeloma Yan Yan-hong☆． of searchCNKI