四君子汤对早产儿30例免疫功能的影响.DOCVIP

临床医学论文-四君子汤对早产儿30例免疫功能的影响 ?????????????? 作者：欧彩香, 张水堂, 李盛强, 周守方, 袁贵龙, 张柱林 【摘要】? 目的 探讨四君子汤对早产儿免疫功能的影响。方法 将60例早产儿随机分成两组,对照组按《早产儿管理指南》予常规早产儿诊疗及护理,观察组在对照组的基础上加服四君子汤。观察两组治疗前后的免疫功能变化，并观察药物不良反应。结果 治疗后两组间比较IgG，IgA，CD3，CD4差异有统计学意义(P0.05);观察组医院感染率为6.7%，对照组医院感染率为26.7%，两组差异有统计学意义(P0.05)。喂服四君子汤无副反应。结论 四君子汤通过调节T淋巴细胞亚群和免疫球蛋白来改善免疫功能，提高机体免疫力，减少医院感染，有利于治疗顺利进行。 【关键词】? 婴儿，新生，早产; 四君子汤/治疗应用; 免疫功能; 交叉感染 　　【Abstract】 Objective To investigate the curative effects of Sijunzi decoction on immune function of the premature infants.Methods A total of 60 cases of premature infants were randomly divided into traditional Chinese medicine treatment group and control group.The control group was treated with conventional treatment according to Management guidelines for premature infants.The treatment group was treated with Sijunzi decoction orally taken in addition to the conventional treatment.Observe the immune function change and the sideeffects in the two groups before and after treatment.Result After treatment,CD3,CD4,IgG and IgA were significantly increased in the treatment guoup compared with control group,the difference being statistically significant (P0.05).In treatment group the incidence of hospital infection was 6.7%,while in control group,the incidence of hospital infection was 26.7%,which had statistically significant difference (P0.05).There was no sideeffect in the treatment group.Conclusion By regulating the Tlymphocyte subsets and immunoglobulin，Sijunzi decoction can regulate cellular immune function,enhance the body immunity，and reduce hospital infection，contributing to the treatment. 　　【Keywords】 Premature infants; Sijunzi decoction; Immune function; Crossinfection 　　早产儿又称未成熟儿，指胎龄37周的新生儿。流行病学研究报告早产儿的发生率为12%，其中90%的早产儿需要新生儿重症监护;国内早产儿发生率为5%～10%[1]。随着围产医学的不断发展和新生儿重症监护病房(NICU)救治水平的提高，早产儿早期严重并发症多能得到有效控制，所以早期严重并发症死亡的比例明显下降。然而，早产儿因生活能力低下，需住院时间长，发生医院感染概率高，文献报告NICU医院感染率为25%以上[2]，尤其出生体质量≤1 500 g者感染发生率更高。本文旨在观察中药四君子汤提高早产儿免疫功能的作用，现将结果报道如下。 　　1 资料与方法 　　1.1 临床资料 200801～200903在广州中医药大学附属南海妇产