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19 1 Vol. 19, No. 1
2007 2 Chinese Bulletin of Life Sciences Feb., 2007
1004-0374(2007)01-0097-07
· ·
410081
Q51; R73 A
Separation and identification progress in cancer comparative proteomics
LI Xuanwen, CHEN Ping, ZHANG Lijun, LIANG Songping*
(The Laboratory of Protein Chemistry and Proteomics, College of Life Sciences,
Hunan Normal University, Changsha 410081, China)
Abstract: With the human genome sequence now determined, the field of cancer research is moving beyond
genomics to proteomics. The comparative strategies involving in the cancer proteomic research have been
developed, including cancer sample preparation, proteins or peptides separation, protein identification,
bioinformatics, protein quantification and so on. All these will accelerate the identification of cancer markers
that could be important in early detection, diagnosis and monitoring efficacy of treatment, and also the devel-
opment of protein-based, cancer-specific targets, which have a great effect on cancer medicine. In this review,
we focused on the sample separation and identification progress in cancer comparative proteomics.
Key words: cancer; comparative proteomics; two-dimensional electrophoresis; liquid chromatography; quanti-
fication proteomics
[1-2]
Medline
1997
DNA RNA
2006-03-03 2006-06-26
973 (2001 CB5120)
(1980 ) (1946 ) * E-mail:
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