养正消积胶囊减轻胃癌术后化疗不良反应的临床观察.pdfVIP

养正消积胶囊减轻胃癌术后化疗不良反应的临床观察 ＊ 苏连明 ，李海林，王加良（牡丹江医学院附属红旗医院消化内科，黑龙江牡丹江 157001） 中图分类号 R283.65；R735 文献标志码 A 文章编号 1001-0408（2014）07-0657-03 DOI 10.6039/j.issn. 1001-0408.2014.07.28 摘 要 目的：观察养正消积胶囊对胃癌术后化疗不良反应的疗效。方法：62例胃癌术后患者随机分为两组，治疗组34例给予常 规FOLFOX-4（奥沙利铂+ 5- 氟尿嘧啶+ 亚叶酸钙）化疗方案加用养正消积胶囊，每次4粒，每日3次；对照组28例单纯应用 FOLFOX-4化疗方案。化疗结束后观察两组患者外周血象变化、生存质量及不良反应。结果：与对照组比较，治疗组外周血白细 胞、血红蛋白与血小板下降幅度更小，差异有统计学意义（P ＜0.05）；且治疗组KPS 生存质量评分较高，不良反应较小（均P ＜ 0.05）。结论：养正消积胶囊可减少胃癌术后化疗的不良反应，提高患者生存质量。 关键词 养正消积胶囊；胃癌；化疗；不良反应 Clinical Observation of Yangzheng Xiaoji Capsules in the Treatment of ADR Induced by Chemotherapy after Gastric Cancer Surgery SU Lian-ming ，LI Hai-lin ，WANG Jia-liang （Dept. of Gastroenterology ，The Affiliated Hongqi Hospital of Mudan- jiang Medical University ，Heilongjiang Mudanjiang 157001，China ） ABSTRACT OBJECTIVE ：To observe therapeutic efficacy of Yangzheng xiaoji capsules for ADR induced by chemotherapy after gastric cancer surgery. METHODS ：62patients underwent gastric cancer surgery were randomly divided into 2 groups ；34 cases in treatment group were treated with conventional FOLFOX-4 chemotherapy regimens （oxaliplatin + 5-fluorouracil + calcium folinate） combined with 4 pills of Yangzheng xiaoji capsules ，3 times a day ；28 cases of control group were only used FOLFOX-4 chemo- therapy. After chemotherapy ，the change of peripheral hemogram ，quality of life and other ADR were observed in 2 groups. RE- SULTS ：Compared with control group ，peripheral white blood cell ，hemoglobin and platelet of treatment group decreased greatly ， there was statistical significance （P ＜0.05）；high KPS score and slight ADR were found in treatment group （all P ＜0.05）. CON- CLUSIONS ：Yangzheng xiaoji capsule can reduce ADR induced by chemotherapy after gastric cancer operation and improve the quality of life. KEYWORDS Yangzheng xiaoji capsule ；Gastric can