不同肤色人种皮肤对硫酸月桂酯钠引发刺激性接触性皮炎反应差异的比较.x.docxVIP

不同肤色人种皮肤对硫酸月桂酯钠引发刺激性接触性皮炎反应差异的比较不同肤色人种皮肤对硫酸月桂酯钠引发刺激性接触性皮炎反应差异的比较中华皮肤科杂志 1999年第6期第32卷 论著作者：陆洪光　张宁　Graves　C　MarksR单位：陆洪光　张宁　550001贵阳医学院附属医院皮肤科；GravesC　MarksR　英国威尔士大学医学院皮肤科关键词：皮炎；刺激性硫酸月桂酯钠皮肤【摘要】目的　评估不同肤色人种皮肤对化学刺激物的敏感性。方法　用多个浓度的硫酸月桂酯钠对32例健康志愿者(黑种人8例，白种人16例，黄种人8例)背部皮肤进行斑贴试验。结果　显示黑种人组最小红斑刺激量高于白种人组(P＜0.05)和黄种人组0.05)。然而在相同浓度的硫酸月桂酯钠刺激部位，黑种人、白种人和黄种人3组经表皮水分散失和真皮浅层微血管血流量值无显著性差异。黑种人、白种人和黄种人3组经表皮水分散失和真皮浅层微血管血流量值分别与硫酸月桂酯钠刺激浓度有明显的剂量应答关系，并且3组经表皮水分散失值与临床观察指数值之间呈显著正相关(黑种人组：r=0.83，P＜0.01；白种人组：r=0.92，P＜0.01；黄种人组：r=0.89，P＜0.01)。结论　与白种人和黄种人相比，黑种人皮肤对硫酸月桂酯钠刺激同样较敏感。Racial Difference in Sodium Lauryl Sulphate Induced Cutaneous Irritation-A Comparison Between the Skin of White, Black and Oriental RaceLU Hongguang* , ZHANG Ning, GRAVES C,et al.*Department of Dermatology, Affiliated Hospitalof Guiyang Medical College, Guiyang 550001【 Abstract】 Objective　To determine the susceptibility to an irritant in the skin of different races. Methods A total of 32 subjects were included in the study and pided into three race groups: 8 Blacks, 16 Caucasians and 8 Orientals. All volunteers were given patch test with sodium lauryl sulphate(SLS) (0.25％ ～ 2％ ) to the skin of upper back for 24 hours. The skin response was evaluated after removing test chambers.Results It was shown that minimal irritant dose(MID) levels were significantly higher in Blacks than those in Caucasions (P＜0.05) but not in Orientals 0.05). It was observed that values of the transepidermal water loss (TEWL) and laser doppler velocimetry(LDV) increased significantly along with the increase of dosage of SLS in each of three race groups. There was no difference in values of TEWL and LDV among Caucasion, Black and Oriental groups. Furthermore, it was found that TEWL values significantly correlated with the visual scores in the three groups(Blacks r=0.83,P＜0.01, Caucasions r=0.92,P%26lt; 0.01, Orientals r=0.89, P＜ 0.01).Conclusion The resuts indicate that dark skin has the same sensitive response to SLS irritation as light skin.【 Key words】 De