经典与非经典抗精神病药物维持治疗对精神分裂症患者转归的影响.pdfVIP

江医学2013 年第35 卷第23 期 临床研究 经典与非经典抗精神病药物维 持治 对精神分裂症患者转归 的影响 朱丞 王奕權 曹阳光 陈致宇 【摘要 】 目的 比较经典与非经典抗精神病药物长期维持治 对精神分裂症患者转归的影响。 方法 选择255 例出院的精 神分裂症患者，依据其出院后 1 月且病情稳定时服用的治疗药物，分为经典抗精神病药物治 组（经典组）和非经典抗精神病药物治 组（非经典组），进行为期2 年的随访观察。分别用阳性及阴性症状量表（PANSS ）、生活质量量表（SQOL ）、 人和社会功能量表 （PSP ）和不良反应量表（TESS ）评估患者的症状、生活质量、社会功能及药物不良反应。结果 与基线期相比，经典组与非经典组患者 在随访2 年时PANSS 评分及SQOL 评分均显著下降；但两组间PANSS 及SQOL 评分差值的差异均无统计学意义。与基线期相比， 在随访2 年时，经典组患者PSP 评分与基线期的差异无统计学意义；而非经典组患者PSP 评分较基线期均有显著性提高；且两组之 间PSP 评分差值的差异有统计学意义。非经典组体重增加的发生率显著高于经典组。结论 精神分裂症患者长期服用非经典抗精神 病药物维持治 ，效与经典抗精神病药物相当，并且药物不良反应更少，能够获得更好的生活质量及社会功能。 【关键词】 精神分裂症 抗精神病药 转归 随访 Effects of typical and atypical antipsychotic maintenance treatment on outcome in patients with schizophrenia China 【Abstract 】 Objective To compare the effects of typical and atypical antipsychotic maintenance treatment on outcome in patients with schizophrenia. Methods A total of 255 inpatients included from June 2009 to September 2011 were divided into two groups: the typical antipsychotics group(Typical Group) and the atypical antipsychotics group(Atypical Group) according to the drugs they took a month after discharge from hospital and in stable condition. Symptoms, quality of life, social function and adverse reaction of all patients were assessed with the Positive and Negative Symptoms scale (PANSS), the Self-report quality of life scale (SQOL ）, the Personal and Social performance scale (PSP), and the Treatment Emergent Symptom Scale (TESS) at baseline, half a year, one and two years after. Results At the end of the follow up, the atypical groups total PSP scores were significantly higher than typical group; the total PANSS score and the total SQOL score of atypical group were lower than typical group, but there was no s