_a期非小细胞肺癌术后放疗和化疗的失败原因分析_汪虹.pdfVIP

　2000 1 　 15 1 　T he P act ical Jou nal of C an ce , Janua y 2000, V ol.15, No.1 ·51 · Ⅲ a 汪　虹　郎锦义　周筱秋　冉晓东　王静波 　　【】　　Ⅲa 。　Co x , 107 Ⅲ /。　(S)、+ a (S +C)、+(S+R)、++(S+R+C)5 20.8%、24.3%、25.0 %、34.6%。 5 88.5%, 69.2%(P0.05)。21.8 , 14.8 , 4 5 。N (P=0.0 13), (P =0.0586)。　N 2 。 【】　;;;; :R734.2;R 73-31　　:A 　　:100 1-5930(2000)01-0051-03 Patterns of DiseaseFailureof Postoperation Radiotherapy and Chemotherapy in Radically Resected Stage Ⅲ Non-small-cellLung Cancer a WA N G H ong , L A N G J in-y i, Z H O U X iao-qiu , et al .　M ainy ang Cen tral H osp ital, M iany ang, 62 1000 【Abstract】　Objective　T o study the benefit and failu e patte ns of adiothe apy a nd chemo the apy follow ing adical su ge y in stage Ⅲ non-small cell lung cance (N SCLC). ethods　U niva iate and multiva iate Cox analy ses we e pe fo med.T he the apeutic a effects of su ge y alo ne(S), plus chemo the apy (S +C), plus adiothe apy (S+R)and plus adiochemothe apy (S +R+C)in 107 cases w e e ev alua ted.T he 5-y ea su vival ate w as 20.8%(S), 24.3%(S +C), 25.0%(S +R)a nd 34.6%(S +R+C)espectively (P0. 05).Results　T he 5-y ea local failu e-f ee su v iv al ate w as 88.5%in the pa tients eceived adiothe apy, in o the s, it w as 69.2%(P 0.05).T he distant me tastases time in the pa tients eceived chemothe apy was 21.8 ±8.5 months and it w as 14.8±7.8 mo nths in o the s(P0.05).How eve , the 5-yea distant metastases-f ee su vival ates w e e no t diffe ent in all fou g oups (P 0.05).O n multiva iate analy sis, o nly N stag e w as the independent p og nostic facto (P =0.013).N 2 ly mph nodes invo lved was the hig h isk fac- to of distant metastases.Conclusion　F o pa tients w ith N 2 stage, S+R+C should be a bette the apeutic modality . 【Key words】　L ung cance ;N o n-small-cell lung ca cinoma;Su ge y;Radio the apy;Chemothe apy (The P ractical J ournal o Cancer , 20