中山市体检人群非酒精性脂肪肝危险因素的病例对照研究(投稿).docVIP

非酒精性脂肪肝危险因素的病例对照研究 钟淑婷1 李燕青2 将卓勤3 王林静4 (1.广州医学院第三附属医院临床营养科,广州，510150;2.中山市博爱医院营养室，中山，528403;3.中山大学公共卫生学院营养系教授，广州，510080;4.广东药学院预防医学系副教授，通信员，广州，510310) 摘要：[目的] 探讨中山市体检人群非酒精性脂肪肝(NAFLD)的危险因素。[方法] 将经B超确诊的非酒精性脂肪肝患者按年龄、性别作1:1配对进行病例对照研究，共306对。[结果] 单因素分析结果显示超重及肥胖、血糖代谢紊乱、高血压、血脂异常、高尿酸血症、胆囊结石、喜食甜食、喜食零食、经常睡前加餐、常食肉类、常食煎炸食物、常食蔬菜、常食水果、经常饮茶、经常运动与NAFLD关系密切；多因素分析结果显示超重及肥胖、血糖代谢紊乱、高血压、血脂异常是NAFLD的危险因素，常食蔬菜、常食水果、经常饮茶、经常运动是NAFLD的保护因素。[结论] 积极治疗、控制原发病，加强对饮食结构及生活方式的干预是有效防治非酒精性脂肪肝的关键。 关键词:非酒精性脂肪肝，危险因素，病例对照研究 ABSTRACT：[Objective] explore risk factors of nonalcoholic fatty liver of health examination people in ZhongShan. [Methods] 306 cases of NAFLD and 306 controls who are diagnosed by B-ultrasonic examination are conducted by a 1:1 matched case-control study. [Results] It shows NAFLD has a close relationship with overweight or obesity, blood glucose metabolic disorders, hypertension, abnormal blood lipids, hyperuricemia, gallstone disease, fond of eating sweet food, fond of eating snacks, extra-meal before sleep, frequently eating meat, frequently eating fried food, frequently eating vegetables, frequently eating fruits, frequently drinking tea, and doing more exercise by using single-factor analysis. Multi-factor analysis indicates that the following factors: overweight or obesity, blood glucose metabolic disorders, hypertension, and abnormal blood lipids are the risk factors of NAFLD. Frequently eating vegetables, frequently eating fruits, frequently drinking tea, and doing more exercise are the protective factors of NAFLD. [Conclusion] Treating actively and controling protopathy, strengthening the intervention on diet structure and life styleare the key points to prevent fatty liver. Key words: nonalcoholic fatty liver, risk factor, case-control study 近年来，随着生活水平的提高，生活方式和饮食习惯的改变，非酒精性脂肪肝(NAFLD)的患病率不断上升，:1配对，共306对。排除标准：病毒性肝炎、药物性肝炎、自身免疫性肝炎、肝豆状核变性、全胃肠外营养、各重要脏器的器质性病变、妊娠或哺乳期妇女。 1.2调查方法 采用自行设计得流行病学调查表进行调查，调查表为自填式，由经过统一培训的医务工作人员面对面的指导及监督体检者填写调查表。调查内容主要包括：年龄、性别、婚姻状况、文化程度、职业、收入水平、身高、体重、血压、饮食习惯、