干扰素α-2b联合三氧治疗慢性乙型肝炎效果.pdfVIP

干扰素α-2b联合三氧治疗慢性乙型肝炎效果 目的：探讨干扰素(Interferon,IFN)α-2b联合三氧治疗慢性乙型病毒性肝炎 (Chronic hepatitisB,CHB)患者的临床疗效。 免费咨询电话：4006-828-820网址： QQ 群： 141422077 方法：将60例慢性乙型肝炎患者随机分为两组:对照组30例,接受干扰素α-2b治 疗,500万U,肌肉注射,3次/周;治疗组患者30例,在使用干扰素α-2b治疗的同时, 加用三氧自体血回输疗法。两组患者干扰素使用疗程均为24周。分别在治疗开始 前、治疗12、24周以及治疗停药后24周观察CHB患者血清谷丙转氨酶(ALT)、HBeAg 定量以及HBV-DNA水平的变化。 结果：干扰素α-2b联合三氧治疗组血清HBeAg阴转率、HBVDNA阴转率、完全应 答率明显高于干扰素α-2b 治疗组(P0.05),ALT 复常率两组无明显差异 (P0.05)。 结论：干扰素α-2b联合三氧治疗慢性乙型肝炎的疗效优于单用干扰素α-2b。 [关键词]干扰素α-2b三氧治疗乙型肝炎,慢性 [中图分类号]R575.1[文献标识 码]A Clinical study of interferonα-2b combined with ozone therapy in the treatment of chronichepatitis B YANG Yan,FAN Yü-chen,WU Juan,et al.Department of Hepatology,Qilu Hospital ofShandong University,Jinan 250012,China [Abstract]Objective To study the effect of interferonα-2b combined with ozone therapy in thetreatment of chronic hepatitis B.Methods Sixty patients with chronic hepatitis B were divided into twogroups.Thirty patients treated with interferonα-2b plus ozone therapy were taken as a treatment group.The other thirty patients receiving interferonα-2b therapy alone were as a control group.Their coursesof treatment were all for 24 weeks.The percentage of HBeAg HBVDNA negativity,thenormalizedratesofALTwerestudiedatinitial12weeks,24 weeks and post-treatment 24 weeks.Results Thepercentage of HBeAg and HBVDNA negativity and the complete response rate of the group treated withinterferonα-2bweresignificantlyhigherthanthegrouptreatedwith interferonα-2bcombinedwithozonetherapy(P0.05).Thenormalizedrates of ALT showed no significant differences(P0.05).Conclusion Compared with interferonα-2b alone,α-interferon combined with ozone therapy is moreeffective for treating patients with chronic hepatitis B. [Key words]Interferon Ozone therapy Hepatitis B,chronic 慢性乙型病毒性肝炎(ChronichepatitisB,CHB)是我国的常见病、多发病, 是引起肝硬化、肝癌的最主要的原因。干扰素α-2b(IFNα-2b)是最早公认的抗 乙型肝炎病毒(Hepatitis B virus,HBV)的主要药物,其HBeAg血清转换率为 15%～37%。三氧是一种有三个氧原子组成的强氧化