真武汤联合顺铂腹腔化疗治疗晚期肝癌腹水临床观察.docVIP

真武汤联合顺铂腹腔化疗治疗晚期肝癌腹水临床观察 王静1 贾彦焘2 （1.天津中医药大学，天津300193；2.天津中医药大学第一附属医院，天津300193） 【摘要】目的：观察真武汤联合顺铂腹腔化疗治疗晚期肝癌腹水的临床疗效。方法：将56例晚期肝癌腹腔积液患者随机分成2组，分别采用真武汤联合顺铂（DDP）腹腔灌注化疗和单纯使用顺铂腹腔灌注化疗。4周后，评价其疗效。结果：治疗组有效率82.14%， 对照组有效率60.71% ，两组有显著差异性（P0.05）。结论：治疗组可明显提高有效率，提高患者生存质量，且无明显副作用。 【关键词】真武汤 顺铂 腹腔化疗 晚期肝癌腹水 The Clinical Observation of Zhenwu Decoction and Intraperitoneal Chemotherapy with Cisplatin for Malignant Ascites of Advanced Hepatic Carcinoma Wang Jing1 Jia Yantao2 【Abstract】: Objective: The clinical observation of Zhenwu decoction and Intraperitoneal chemotherapy with cisplatin for malignant ascites of advanced hepatic carcinoma. Methods: 56 patients with malignant ascites of advanced hepatic carcinoma were randomly divided into 2 groups, 28 patients with malignant ascites of advanced hepatic carcinoma were treated with Zhenwu decoction and intraperitoneal chemotherapy of cisplatin through peritoneal perfusion. 28 patients, served as controls, were treated with intraperitoneal chemotherapy with cisplatin only. After 4 weeks, the curative efficacy was evaluated. Results: The valid rate of Zhenwu decoction and intraperitoneal chemotherapy of cisplatin is 82.14%, the valid rate of comparison group is 60.71%, the difference of the two groups is significant (P0.05); Conclusion: Zhenwu decoction and intraperitoneal chemotherapy of cisplatin is effective for malignant ascites of advanced hepatic carcinoma and benefited to improved quality of life. 【Key Words】: Zhenwu decoction; cisplatin; intraperitoneal chemotherapy; malignant ascites of advanced hepatic carcinoma. 恶性腹水是晚期肝癌常见的并发症，治疗十分棘手，预后差，是当今尚未攻克的难题。腹腔内灌注化疗是一种较常用而且有效的治疗方法，但是有一定的毒副反应，严重影响患者的正常治疗。我院自2007年6月～2008年5月将收治的晚期肝癌术后并发腹腔积液患者56例随机分成两组，分别采用真武汤联合顺铂（DDP）腹腔灌注化疗和单纯使用顺铂腹腔灌注化疗。结果显示真武汤对改善晚期肝癌腹水症状及减轻腹腔化疗副反应具有显著疗效。现将结果报道如下： 1 一般资料 1.1对象 56例中男34例，女22例，年龄45～78岁。均经病理学检查已确诊为晚期肝癌并发腹腔积液，曾接受肝癌肿块切除术，治疗前均进行腹部B超探察证实为腹腔中等至大量积液。随机分成真武汤联合腹腔化疗组和单纯腹腔化疗组，每组各28例。住院期间患者近1个月未接受放疗和化疗治疗，未使用胸腺肽和干扰素等免疫制品和放腹水等治疗。 1.2 方法 患者仰卧位，以左侧髂前上