New mechanism revealed for regulation of autoimmunity.pdfVIP

维普资讯 固W盯CH Biology Newmechanismrevealedforregulation - ■ ■ otautoimmunIty healthyhumanbody is ingand directingotherimmune survivalandautoimmunity． equippedwithapowerful cells，andareparticularlyimportant Theirstudiesdemonstratethatthe I。mmunesystem forresist— in theimmune system ．However， multiufnctionaladaptorproteinB— ing the attack of invading theyaremaintainedinahomeostatic arrestin1，agroupofproteinsthatis microorganisms．Unfortunately,the balancebetweentheirproduction importantforregulatingsignaltransduc— system sometimesgoesawryandat— and elimination．Otherwise，their tionwithincells，positivelyregulated tacksthebodyitself．Autoimmunity dYsregu1ation can cause nativeandactivatedCD4 T cell isthefailureofanorganism torec— autoimmunity． surviva1．Th eriexperimentsshow htat ognlzeitsownconstituentpartsas After m anY Years of micedeficientinthegeneencoding s‘‘elf,”resultingin animmunere— cooperation，two research teams 13．arrestin1weremuchmoreresistant sponseagainstitsown cellsand headedrespectivelybyPEIGang toexperimentalautoimmune．Asre． tissues．A disorderthatresultsfrom andZHANG Jingwu，bothrfom the portedonlineon9JuneinhteNature suchanaberrantimmuneresponseis CAS ShanghaiInstitutesforBio— Immunity，htestudiesindicatehtatB— termedanautoimmunedisease． logicalSciences，havemade en— arrestin1iscriticalofrCD4+T cell CD4+T cells．amemberofwhite couragingprogressintheirstudies survivalandisaf