早期DN中医证候与阴阳体质相关性研究.doc

早期DN中医证候与阴阳体质相关性研究 陈静1﹡ 秦源1 曹峰1 徐寒松2 毛奇2 杨传经2 （1贵阳中医学院基础部; 2贵阳中医学院第二附属医院内分泌专科﹡） 通讯作者：曹峰 邮箱cflzhfe@126.com 手贵州省科技厅联合基金项目（No.2010LKZ7016）； 贵州省中管局中医药、民族医药科学技术研究课题（No.QZYY2010） 【摘要】 目的 研究早期DN患者中医证候与阴阳体质的相关性，为DN的防治提供理论依据。 方法 选取符合西医诊断标准的早期DN样本，共111例，按体质分为阳脏人、阴脏人以及阴阳平和人三类。比较3种体质在相关实验室指标、中医证候等方面的不同特点。 结果 早期DN患者阴脏人BMI中超重及肥胖人高于阳脏人及阴阳平和人（P0.01）。尿微量白蛋白显示阳脏人与阴脏人有差异（P0.05）。阳脏人者出现阴虚燥热证者显著高于其余两种体质患者（P0.01）。阴脏人出现气阴两虚、脾肾两虚证者高于阳脏人及阴阳平和人(P0.05)。结论 早期DN中医证候与阴阳体质之间存在一定相关性。 【关键词】 早期糖尿病肾病；阴阳体质；中医证候 Correlativity Study is based on Early Diabetic Nephropathy of TCM Syndromes and Yin-yang constitute [ABSTRACT]Objective: Study on correlation between Early Diabetic Nephropathy(DN) of TCM Syndromes and Yin-yang constitute, in order to provide theory basis for treatment and prevention of early DN. Method: Accord with Western medicine diagnostic standard described above early DN, selected 111 samples divided into three groups with constitute: Yang-zang person, Yin-zang person and Yin-yang mild person. Comparison different characteristics of 3 different physicals in correlation laboratory indexes, TCM Syndromes and complications. Result: Yin-zang person of Early DN patients appeared BMI about overweight and obesity subjects higher than Yang-zang person and Yin-yang mild person (p0.01).Uric micro-albumin showed that Yang-zang person has differences with Yin-zang person (p0.05). Yang-zang person appeared Yin-deficiency and dryness-heat syndromes more than the other two types person(p0.01). Yin-zang person appeared deficiency of both qi and yin、deficiency of both spleen Qi and kidney Qi syndrome higher than the other two types in early DN (p0.05). Conclusion: Early DN existing cerain correlation between TCM Syndromes and Yin-yang constitute. [Key Words] Early diabetic nephropathy(DN); Yin-yang constitute; TCM syndromes 糖尿病肾病(diabetic nephropathy , DN)是糖尿病（Diabetes Mellitus，DM）患者最常见、最严重的微血管并发症，是现今公认的终末期肾脏损害最常见的致病原因，也是公认的心血管疾病独立的风险因素 [1]。Wild等研究称，至2030年全世界将有37亿DM患