AntiviralWarrior—APOBEC3G：抗病毒的武士APOBEC3G.pdfVIP

Dec. 2005 Journal of Electronic Science and Technology of China Vol.3 No.4 * Antiviral Warrior —APOBEC3G WU Xiao-xia, MA Yi-cai (School of life science and technology, University of Electronic Science and Technology of China Chengdu 610054 China) Abstract This paper is to further understand how APOBEC3G can defend the retroviruses and to find new approaches to AIDs (acquired immure deficiency syndrome).The viral infectivity factor (Vif) induces rapid degradation of APOBEC3G by ubiquitination, which is a proteosome-dependent pathway. Precisely speaking, only in the virus-producing cell Vif expression is necessary; in its absence, infection of a subsequent target cell terminates at a postentry step through the action of the human APOBEC3G antiviral mechanism. Vif protein has two domains: one binds to APOBEC3G and the other regulates the degradation of APOBEC3G by a conserved sequence, SLQ (Y/F) LA motif. Recently, the research on Vif has also revealed APOBEC3G is a novel component of innate immune system. In fact, APOBEC3G not only acts in DNA editing to block the replication of retroviruses such as HIV-1, but also is able to defend a wide spectrum of distantly related retroviruses and interferes with HBV through a different mechanism from HIV. Key words HIV-1; CEM15/APOBEC3G; Vif; hypermutation; innate immunity; HBV Vif which consists of 192 amino acids is a Mr~23 immune system is competing at all the times in the protein encoded by the human immunodeficiency virus