AssociationsofSAA1genepolymorphismwithLipidlelvels：的SAA1基因多态性与血脂lelvels协会.pdfVIP

Feng et al. Lipids in Health and Disease 2013, 12:39 /content/12/1/39 RESEARCH Open Access Associations of SAA1 gene polymorphism with Lipid lelvels and osteoporosis in Chinese women 1* 1 2 1 1 1 1 2 Zheng-Ping Feng , Xiao-Yu Li , Rong Jiang , Hua-Cong Deng , Mei Yang , Qin Zhou , Wen-Jun Que and Jia Du Abstract Background: The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women. Methods: A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P 0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P0.05). Conclusions: The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene. Keywords: SAA1, Genetic polymorphism, Osteoporosis Background of CVD [9]. And serveral stu