生殖器疱疹患者外周血CD14+单核细胞Toll样受体的表达及其意义.pdfVIP

185 论著· 生殖器疱疹患者外周血CDl4+单核细胞 Toll样受体的表达及其意义 钱起丰， 张明霞 (广东省深圳市皮肤病防治研究所，广东 深圳518020) [摘要] 目的：探讨CDl4+单核细胞Toll样受体(TLRs)的表达在复发性生殖器疱疹(RGH)发病机制 中的作用。方法：采用双色免疫荧光抗体染色流式细胞术检测了34例RGH患者外周血单核细胞表面 TLR4、TLRl、TLR2的表达水平，并以36例正常人作为对照。结果：RGH患者外周血单核细胞TLR4的 达水平在以上两组中差异无统计学意义(P0．05))。结论：单纯疱疹病毒感染能上调单核细胞TLR4 的表达，在病毒识别、增强信号传导、启动抗病毒的固有免疫反应中起着重要作用。 [关键词]生殖器疱疹；Toll样受体；单核细胞 [中图分类号]R752．1 [文献标识码]A [文章编号] 1009—8968(2006)03—0185—03 ofToll-like on Blood inPatientswith Expressions ReceptorsPeripheralCDl4+Monocyte Genital Herpes QIANQi-feng，ZHANGMing—xia Institute 51 (ShenzhenofDermatology，Shenzhen8020，China) the ofToll—like CDl4+mOB— [Abstract]Objective：Toexploreexpressions receptors(TLRs)on andtheroleinthe of recurrent pathogenesis herpes(RGH)．Methods：The ocytes genital expres- TLR2on sionof and blood was flow TLR4，TLRl peripheralCDl4+monocytesanalyzedby withtwo--colourimmunofluorescentin34 withRGHand36 cytometry stainingpatients healthy ofTLR4on controls．Results：The was in expression CDl4+monocytessignificantly higherpatients RGH thatin from with than TLRl on RGH controls(P0．001)，but healthy expressedmonocytes was lowerthanthatin wasno differencein controls(P0．001)．There patientsmarkedly