枸橼酸铋雷尼替丁治疗反流性食管炎的疗效和安全性.pdfVIP

拘糠酸秘雷尼替丁治疗反流性食管炎的疗效和安全性 王燕斌，张 磊，梁王霞 (首都医科大学附属北京天坛医院消化内科，北京100050) 【摘要〕 目的:评价构椽酸秘雷尼替丁对反流性食管炎的临床疗效及安全性。方法:将121例LA分级为A一D 级的反流性食管炎患者随机分为3组，实际完成107例，试验组(n=38)予构椽酸秘雷尼替丁350mg,po,bid;对照1组 (n=36)予奥美拉哇40mg,po,qd;对照2组(n=33)予多潘立酮10mg,po,td。疗程均为4周，根据临床症状及胃镜复 查评价疗效。结果:内镜下病变改善情况试验组治愈率为65.79%，总有效率为92.11%;对照1组治愈率为75.00%, 总有效率为91.67%;对照2组治愈率为51.52%，总有效率为78.79%。治愈率和总有效率试验组与对照1组比较差 异无显著性(P0.05)，但均明显高于对照2组(P0.05)。三组均未出现明显不良反应。结论:构椽酸秘雷尼替丁 治疗轻、中度反流性食管炎有效，与经典的质子泵抑制剂治疗方法相比疗效相当，优于单用促动力药多潘立酮。 〔关键词〕 胃食管反流病;反流性食管炎;构橡酸秘雷尼替丁;奥美拉哇;多潘立酮 [中图分类号]R975.6;R969.4 【文献标识码」A 【文章编号」1003-3734(2006)01-0056-03 Clinicalevaluationofthreetherapeuticregimensforrefluxesophagitis WANGYan-bin，ZHANGLei，LIANGPi-xia (DepartmentofGastroenterology，BeijingTiantanHospitalAffiliatedtoCapital UniversityofMedicalSciences，Beijing100050，China) [Abstract] Objective,Tocomparetheefficacyofranitidinebismuthcitrate(RBC)toothertwo therapeuticregimensinthetreatmentoftherefluxesophagitis.Methods:121patientswithrefluxesoph- agitis(LosAnglesclassificationAtoDgrade)wererandomlyassignedintooneof3treatmentgroups: RBC(350mg，bid)，omeprazole(40mg，qd)anddomperidone(10mg，tid)for4weeks.Theefficacy wasevaluatedbasedontheimprovementofrefluxesophagitisbyendoscopy.Results:Thehealingratein threetherapeuticregimenswas65.79%，75.00% and51.52%，respectively.Thetotalimprovement ratewas92.11%，91.67%and78.79%，respectively.Nosignificantdifferencesofthehealingrateand totalimprovementratewerefoundbetweentheRBCgroupandomeprazolegroup.Comparedtothe domperidone-treatedpatients，thehealingrateandtotalimprovementrateinbothRBCandomeprazole showedsignificantdifferences.Patientswerewelltolerated.Conclusion:RBCandomeprazoleprovided bettertherapeuticoptionsinthetreatmentofrefluxesophagitisthandomperidone. [Keyw